Proprietary Vaccine Development Process: Ii-Key-S

Proprietary Vaccine Development Process:
Ii-Key-SARS-CoV-2 Peptide Vaccine
" Run computational vaccinology programs to ID
SARS-CoV-2 epitope sequences (12 – 15 amino
acids)
" Synthesize Ii-Key-SARS-CoV-2 peptides (solid
phase standard FMOC chemistry)
" Collect blood samples & isolate PBMCs from
COVID-19 recovered patients
! Test Ii-Key-SARS-CoV-2 hybrid peptide vaccines
vs. PBMCs and serum
! Conduct EliSpot analysis to test for IFN-, IL-5 and
Granzyme B expression indicating CD4+ and
CD8+ T-cell activation
! Isolate antibodies using Ii-Key-SARS-CoV-2
Peptides
! Test Ii-Key-SARS-CoV-2 peptide-specific
antibodies in virus neutralization and ADE assays
# Select active Ii-Key-SARS-CoV-2 peptides for
human vaccine clinical trials
# Manufacture GMP SARS-CoV-2 peptide vaccine
for clinical and commercial supply
Development Process & Status
Partnerships in
Peptide Vaccine
Development –
Production –
Research &
Distribution
7
" Complete
! Ongoing
# To do

***************remember this slide is about 2 weeks old***********

Also, this slide as all the Peptide Partnership company logo's posted. PPD, 3M etc