Bone marrow transplants carry a high risk of death
Post# of 153818
(Total Views: 624)
Posted On: 07/16/2020 2:10:11 AM
Bone marrow transplants carry a high risk of death, that’s why the aren’t commonly used unless death is near, basically as a last resort. Also to ensure every CCR5 receptor has leronlimab attached to it before an HIV molecule is a pretty tough ask since reservoirs can sleep for 10 years possibly more.
I’ve believed for quite some time as in post below a safer option could be partner with Sangamo ZFN for the following potential cure of HIV
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Posted On: 08/08/2019 6:37:57 AM
Post# of 40894
Posted By: SeeWhyDY
I wouldn’t be surprised if the potential cure strategy talked about would run something like this ........
Use an HIV infected patients stem cells that create T-cells and modify them to reduce the CCR5 receptor length so HIV can not attach.
Then re-insert the modified stem cells back into the same patient thereby giving the patient 2 compatible immune systems one being protected by lerolimab and the other immune to infection. Once the stem cells replicate sufficient T-cells the amount of leronlimab can be reduced leaving some T-cells susceptible to infection which then can be destroyed by the new immune T-cells.
Over time the immune T-cells would outnumber the original T-cells until the bodies newly created immune system can control the infection at which time all drugs can be removed.
This potentially can provide a safe true cure For HIV patients.
I’ve believed for quite some time as in post below a safer option could be partner with Sangamo ZFN for the following potential cure of HIV
============================================
Posted On: 08/08/2019 6:37:57 AM
Post# of 40894
Posted By: SeeWhyDY
I wouldn’t be surprised if the potential cure strategy talked about would run something like this ........
Use an HIV infected patients stem cells that create T-cells and modify them to reduce the CCR5 receptor length so HIV can not attach.
Then re-insert the modified stem cells back into the same patient thereby giving the patient 2 compatible immune systems one being protected by lerolimab and the other immune to infection. Once the stem cells replicate sufficient T-cells the amount of leronlimab can be reduced leaving some T-cells susceptible to infection which then can be destroyed by the new immune T-cells.
Over time the immune T-cells would outnumber the original T-cells until the bodies newly created immune system can control the infection at which time all drugs can be removed.
This potentially can provide a safe true cure For HIV patients.
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