Fauci giving no mention to leronlimab in latest interview during Stanford Medicine event. Looks to be talking about Regeneron IV mab's.
http://med.stanford.edu/news/all-news/2020/07...minor.html
2:45
Minor: If we think about those clinical trials and focus for a moment here in the outpatient setting, you mentioned before briefly some of the things that are being developed, maybe we could discuss those in a bit greater detail. There are monoclonal antibody therapies being developed and in early stage trials now. There are also trials looking at repurposing of other antiviral agents to see if they’re effective in COVID-19. What are you most enthusiastic about? And what are your thoughts about the pace of these trials and whether or not maybe by the fall or winter, we will have a regimen that could be beneficial in the outpatient setting, to a person newly diagnosed with COVID-19? Fortunately, not sick enough to go into the hospital but hopefully increasing the probability that they won’t have to go into the hospital and that their recovery time will be shortened. Where are you most hopeful? Where do you see the progress being made?
23:37
Fauci: Well, given the experiences that we’ve had with Ebola and monoclonal antibodies, I think that that’s almost a sure bet: monoclonal antibodies directly against the virus, to be given in a single or a couple of intravenous infusions to people early in the course of disease, to prevent the necessity of their going into the hospital in advance. So right away that’s up front — they’re going into multiple clinical trials now doing that. Convalescent plasma, I think we need to have some caution about that; you want to make sure you do it right, you’ve got to get the right titer of antibody, because there’s amazing variability in titer of antibodies in people. So the best way to get that done — it’s a little bit more work — is to get the convalescent plasma and do hyperimmune globulin that you could titrate and know exactly what you’re giving to people. The thing I’d like to see more of, and we will see it, is screening of molecules that are pure antivirals that can be given early on. You know remdesivir is an antiviral, but there are polymerase inhibitors and protease inhibitors, and things like that very similar to what we did with HIV that I’d like to see pursued a bit more. So I think by your timeline that you mentioned, sometime in the fall, I think we could conceivably have a couple of more good antivirals as well as anti-inflammatories.
http://med.stanford.edu/news/all-news/2020/07...minor.html
2:45
Minor: If we think about those clinical trials and focus for a moment here in the outpatient setting, you mentioned before briefly some of the things that are being developed, maybe we could discuss those in a bit greater detail. There are monoclonal antibody therapies being developed and in early stage trials now. There are also trials looking at repurposing of other antiviral agents to see if they’re effective in COVID-19. What are you most enthusiastic about? And what are your thoughts about the pace of these trials and whether or not maybe by the fall or winter, we will have a regimen that could be beneficial in the outpatient setting, to a person newly diagnosed with COVID-19? Fortunately, not sick enough to go into the hospital but hopefully increasing the probability that they won’t have to go into the hospital and that their recovery time will be shortened. Where are you most hopeful? Where do you see the progress being made?
23:37
Fauci: Well, given the experiences that we’ve had with Ebola and monoclonal antibodies, I think that that’s almost a sure bet: monoclonal antibodies directly against the virus, to be given in a single or a couple of intravenous infusions to people early in the course of disease, to prevent the necessity of their going into the hospital in advance. So right away that’s up front — they’re going into multiple clinical trials now doing that. Convalescent plasma, I think we need to have some caution about that; you want to make sure you do it right, you’ve got to get the right titer of antibody, because there’s amazing variability in titer of antibodies in people. So the best way to get that done — it’s a little bit more work — is to get the convalescent plasma and do hyperimmune globulin that you could titrate and know exactly what you’re giving to people. The thing I’d like to see more of, and we will see it, is screening of molecules that are pure antivirals that can be given early on. You know remdesivir is an antiviral, but there are polymerase inhibitors and protease inhibitors, and things like that very similar to what we did with HIV that I’d like to see pursued a bit more. So I think by your timeline that you mentioned, sometime in the fall, I think we could conceivably have a couple of more good antivirals as well as anti-inflammatories.
2
