True, safety first. Then, how big an effect are yo

True, safety first. Then, how big an effect are you targeting? Remember statistical precision only grows with the square root of patients: 4x the patients ==> 2x the precision. So, all else equal, a 1600 person trial will have the same confidence in detecting, say, a 20% reduction in death rate, as a 400 person trial has in detecting a 40% drop,

My expectations for leronlimab relative risk reduction in S/C begin at 40%.