$PBIO Ms. Roxana McCloskey, PBI's Global Director of Sales

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$PBIO Ms. Roxana McCloskey, PBI's Global Director of Sales & Marketing, said: "The generation of reliable and reproducible data from biopsy samples is difficult, as it requires the integration of multiple and varied laboratory processes, particularly tissue extraction, sample preparation, and analysis. The innovative LMD-PCT workflow enables the reproducible and rapid extraction of proteins from precious clinical samples by combining the precision of the Leica LMD system with PBI's versatile PCT sample preparation platform. The ability to co-market the workflow offers the opportunity for the combined sales and marketing forces of Leica and PBI to extend the integrated LMD-PCT systems into additional research centers globally that are focused on clinical proteomics, cancer research, biomarker discovery, and precision medicine."

Dr. Falk Schlaudraff, Head of Application Management of Leica Microsystems, commented: "Biomarkers can be used as indicators of certain diseases, such as cancer. They also improve our understanding of the complex tumor microenvironment. There are distinct molecular differences between tumor and non-tumor regions, as well as in the tumor itself. These critical differences can only be deciphered by isolating specific, minute sections of these regions. The combined LMD and PCT systems allow for this separation with high accuracy and speed. Downstream molecular analysis of the different regions will be meaningful since they can be analyzed separately and not as a mixture. We are very excited to combine our LMD system with the power of PCT."

Mr. Richard T. Schumacher, President and CEO of PBI, concluded: "We are delighted to see PBI's PCT-based Barocycler system featured in a pivotal position in this important new tumor processing workflow. Based on results to date, we believe the number of laboratories worldwide performing laser microdissection followed by mass spectrometric analyses will increase at a steady and significant rate, that our Barocycler system will fulfill a critical part of this workflow, that our combined marketing and sales capabilities will result in increased market exposure and acceptance, and that the adoption of this novel new workflow should result in a measurable increase in Barocycler sales before the end of 2020."

About Leica Microsystems

Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis of microstructures and nanostructures. Widely recognized for optical precision and innovative technology, the company is one of the market leaders in compound and stereo microscopy, digital microscopy, confocal laser scanning and super-resolution microscopy with related imaging systems, electron microscopy sample preparation, and surgical microscopy. Leica Microsystems is a Danaher company.

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (OTCQB: PBIO) is a leader in the development and sale of innovative, broadly enabling, pressure-based solutions for the worldwide life sciences and other industries. Our products are based on the unique properties of both constant (i.e., static) and alternating (i.e., pressure cycling technology, or PCT) hydrostatic pressure. PCT is a patented enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient and ultra-high levels to control biomolecular interactions safely and reproducibly (e.g., cell lysis, biomolecule extraction). Our primary focus is in the development of PCT-based products for biomarker and target discovery, drug design and development, biotherapeutics characterization and quality control, soil & plant biology, forensics, and counter-bioterror applications. Additionally, major new market opportunities have emerged in the use of our pressure-based technologies in the following areas: (1) the use of our recently acquired, patented technology from BaroFold, Inc. (the "BaroFold" technology) to allow entry into the bio-pharma contract services sector, and (2) the use of our recently-patented, scalable, high-efficiency, pressure-based Ultra Shear Technology ("UST" platform to (i) create stable nanoemulsions of otherwise immiscible fluids (e.g., oils and water) and to (ii) prepare higher quality, homogenized, extended shelf-life or room temperature stable low-acid liquid foods that cannot be effectively preserved using existing non-thermal technologies.

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