The only one I'm worried about is #3, the results
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Posted On: 06/02/2020 10:15:35 PM
The only one I'm worried about is #3, the results aren't as good as we hope.
In particular, the primary outcome in the m/m study is a clinical score of flu-like symptoms on day 14...but most m/m patients should be over it by then without treatment, so it will be difficult to show statistical significance. Also, with severe/critical trial, the primary outcome is mortality at day 28. A yes-no binomial random variable carries very little information, and the effect would need to be very strong to show statistical significance unless the sample size is large (like 390) but there's talk of early unblinding, with much smaller sample size.
In particular, the primary outcome in the m/m study is a clinical score of flu-like symptoms on day 14...but most m/m patients should be over it by then without treatment, so it will be difficult to show statistical significance. Also, with severe/critical trial, the primary outcome is mortality at day 28. A yes-no binomial random variable carries very little information, and the effect would need to be very strong to show statistical significance unless the sample size is large (like 390) but there's talk of early unblinding, with much smaller sample size.
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