In a lighter Sunday note, there have been some rep

In a lighter Sunday note, there have been some reports of CCR5 being associated with much improved memory (Hyperthymesia), and reports of the CRISP-edited Chinese girls that where given the gene mutation was really to improve their performance.

https://biohackinfo.com/news-crispr-babies-cc...-immunity/

Some scientific experiments with rats indeed have indeed demonstrated that CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. This was discovered on a reverse genetic memory screen. Basically, some mice with heterozygous deletion of CCR5 performed much better than other mice.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5213777/

Their conclusion: CCR5 overexpression leads to learning and memory deficits (we are talking mice here).

However, there exist HAND, or HIV-associated neurocognitive disorders which remain a chronic issue, with significant effects on patients ability to perform activities of daily living, quality of life, employment, medication adherence, and survival.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365228/

CCR5 chemokine receptor neurotropism has been identified as a biomarker of this CNS (central nervous system) disorder.

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“CCR5 chemokine receptor neurotropism Viral envelope glycoproteins can fuse with only those cells expressing both CD4 and an HIV co-receptor, of which CCR5 has been identified as the most important for microglia and CNS macrophages. CCR5 receptors are upregulated on activated CD4+ and CD8+ T cells, enhancing antigen-presenting cell interaction, T cell trafficking into tissues, and cytokine production. In response to infection or inflammation, monocytes, microglia, astrocytes, and neurons express CCR5 ligands, which increase the migration of CCR5+ T cells into the CNS. Locally, these effector T cells secrete CCR5 ligands, which amplify the immune response. A subset of CCR5-tropic viruses have been found to be highly fusogenic, requiring lower expression levels of CCR5 and CD4 to infect cells, leading to greater apoptosis. There is now good evidence that the vast majority of HIV strains in the brain are CCR5 tropic. Given the intrinsic role of CCR5 in CNS disease, it is suggested that CCR5 antagonists, such as maraviroc, may be able to reduce the migration and then activation of effector CD8+ T cells in the CNS and hence reduce the neurocognitive sequelae of HIV. This is now being assessed”

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Quote:

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“A recent prospective, open-label pilot randomized controlled trial in individuals with viral suppression and stable ART for 12 months found maraviroc-intensified HAART improved global neurocognitive performance at both 6 and 12 months without significant side effects”

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So, if Maraviroc works, just imagine what Leronlimab will do in helping with HAND and even improving cognition and memory !!!

Can I have some Nader ??? Pleeeeasseeeeee

Another exciting week ahead of us ... I am hoping for some Oncology data.

GLTU