Below post is from another site. The author IMO i
Post# of 72446
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Posted On: 03/08/2020 11:37:58 PM
Below post is from another site. The author IMO is a doctor highly knowledgeable about 'de novo' drug architecture and Brilacidin in particular.
Makes one realize the power of B:
“One of the holy grails of medicine is to come up with a stable, simple and easy to synthesize organic molecule, one that could be taken orally as a pill, and would function like a protein itself. This truly is one of the great holy grails of pharmaceutical research. The technology that Bill DeGrado and Mick Klein have developed achieves exactly this, using a variety of computational algorithms to mathematically design compounds which mimic the activity of proteins themselves. These compounds can be polymers, which are larger compounds that can be used as materials, and oligomers and small molecules, which can be used as drugs. Thus, biomimetics”.
“We've tested them against more than 25 different bacterial strains, including strains of bacteria that are resistant to antibiotics, and they work against all of them. They also have antifungal and antiviral properties and are very inexpensive and very easy to make. They're safe, selective for bacterial cells, and don't harm mammalian cells. Polymer derivatives of these compounds have been made, and we've shown that we can add them to paints, plastics and textiles to create products and surfaces that are intrinsically and permanently self-sterilizing by virtue of the material itself”.
Makes one realize the power of B:
“One of the holy grails of medicine is to come up with a stable, simple and easy to synthesize organic molecule, one that could be taken orally as a pill, and would function like a protein itself. This truly is one of the great holy grails of pharmaceutical research. The technology that Bill DeGrado and Mick Klein have developed achieves exactly this, using a variety of computational algorithms to mathematically design compounds which mimic the activity of proteins themselves. These compounds can be polymers, which are larger compounds that can be used as materials, and oligomers and small molecules, which can be used as drugs. Thus, biomimetics”.
“We've tested them against more than 25 different bacterial strains, including strains of bacteria that are resistant to antibiotics, and they work against all of them. They also have antifungal and antiviral properties and are very inexpensive and very easy to make. They're safe, selective for bacterial cells, and don't harm mammalian cells. Polymer derivatives of these compounds have been made, and we've shown that we can add them to paints, plastics and textiles to create products and surfaces that are intrinsically and permanently self-sterilizing by virtue of the material itself”.
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