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From wickipedia Mechanism of action PRO 140 is a

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Post# of 153903
(Total Views: 398)
Posted On: 03/02/2020 1:09:37 PM
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Posted By: Rubraquercus
Re: Rubraquercus #19939
From wickipedia
Quote:
Mechanism of action
PRO 140 is a lab-made antibody that functions as an entry inhibitor.[14][15] PRO 140 binds to the CCR5 receptor on the CD4 cells, and interferes with HIV's ability to enter the cell. PRO 140, a humanized form of a PA14 antibody, is a chemokine-receptor CCR5 monoclonal antibody and can inhibit CCR5 tropic HIV-1 at concentrations that do not antagonize the natural activity of CCR5 in vitro. HIV-1 entry is mediated by the HIV-1 envelope glycoproteins gp120 and gp41. The gp120 will bind CD4 and the CCR5co receptor molecule, and this triggers gp41-mediated fusion of the viral and cellular membranes. CCR5 is needed for the entry of the virus and the infection of healthy cells. PRO 140, the anti-CCR5 monoclonal antibody, can stop HIV from entering the cell and stop viral replication. It prevents the virus-cell binding at a distinct site in the CCR5 co-receptor without interfering with its natural activity. Unlike other entry inhibitors, PRO 140 is a monoclonal antibody. The mechanism of inhibition is competitive rather than allosteric.[16] As such, it must be injected to be effective. However, once inside the body, PRO 140 binds to CCR5 for >60 days,[17] which may allow for dosing as infrequently as every other week.[18][19] Compared to highly-active antiretroviral therapy, which has been shown to have treatment-related toxicities for HIV-infected patients, PRO140 has no multi-drug resistance or toxicities.



I would love to have this in a form as it relates to cancer and/or as it relates to Corona.

P.s. the Bat story is obviously intriguing and could be argued as the epicenter of the entire thing. They eat bats in china, and the bats are plentiful in caves knee deep in guano (bat poo) and very dangerous to the lungs from any bats.


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