Downtown on SA got in touch with Nader as to the r
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Posted On: 02/09/2020 6:26:47 PM
Downtown on SA got in touch with Nader as to the rationale for 350mg in the basket trial:
"So I asked NP why the decision was made to use 350mg for the basket cancer trial when higher doses were seen as safe, and if he wasn’t worried that this lower dosage would negatively impact efficacy?
He answered:
“We will address all this at our next presentation. For now please note that 350, 525, and 700 mg all will be considered and our amazing results for patient #1, 3 and 4 were with 350 mg. Patient #2 was allowed to receive 700 mg.”
Not sure about anyone else, but I was unaware that patients #1, 3 & 4 were treated at 350mg. I guess I assumed 700mg, but now that I think about it, it makes sense as this is probably what the FDA wanted for the mTNBC trial at the time. This fact makes the cancer results even a little more impressive, and makes one wonder what extra effects, if any, the higher doses might bring?
Thanks to NP for answering and so quickly."
"So I asked NP why the decision was made to use 350mg for the basket cancer trial when higher doses were seen as safe, and if he wasn’t worried that this lower dosage would negatively impact efficacy?
He answered:
“We will address all this at our next presentation. For now please note that 350, 525, and 700 mg all will be considered and our amazing results for patient #1, 3 and 4 were with 350 mg. Patient #2 was allowed to receive 700 mg.”
Not sure about anyone else, but I was unaware that patients #1, 3 & 4 were treated at 350mg. I guess I assumed 700mg, but now that I think about it, it makes sense as this is probably what the FDA wanted for the mTNBC trial at the time. This fact makes the cancer results even a little more impressive, and makes one wonder what extra effects, if any, the higher doses might bring?
Thanks to NP for answering and so quickly."
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