The ROI is irrespective of the needs or wants of a

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The ROI is irrespective of the needs or wants of an individual investor.

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Yes, you are right, ROI of a investment, but there is such a thing of ROI of a portafolio. My point was that in some instances the optimum utilization of capital might dictate moving (investing) monies around with higher frequency.

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For a BO anytime soon will any company offer us even close to the potential peak in CYDY? Will a larger company's share price appreciate at the same rate or even close to CYDY?

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No, likely not IF oncology works out. I can't think of an investment right now that approaches this potential. That is why I violated ALL my personal money management & diversification rules and over-overweighed CYDY.

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Even if the FDA won't approve early we should start really kicking ass within 3 1/2 - 4 years.

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Precisely the point, some don't have 4 years to wait ... Let's asume you are 70 years old. Question: do you prefer $10 dollars now or probable $100 in 4 years? (you would be surprised by the answers).

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I fully expect a $100 share price at that time.

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Agreed, my model shows even higher SP IF oncology works.