What is most important is the lowering of LDL chol
Post# of 148165
(Total Views: 409)
Posted On: 12/14/2019 1:38:47 PM
Re: the lawman #12694
What is most important is the lowering of LDL cholesterol and raising HDL cholesterol. In the trial what was the p value for LDL - p=.116. The p value for HDL - p=.337. A p value higher than .05 is not statistically significant.
I'm also wondering why the average triglyceride levels of patients in the test was 253 mg/dl. Which is decidedly at the lower levels of the high scale for triglycerides (200 mg/dl -500 mg/dl).
Vascepa approval was for very high range > 500 mg/dl. in the MARINE trial for triglycerides it achieved 27% reduction from baseline. In the MTND trial MAT9001 showed 33% from baseline vs. 10.5% for Vascepa even though Vascepa had a similar percentage in HDL and a much, much better percentage in LDL.
Something seems a little fishy.
MAT9001 results
Vascepa results
I'm also wondering why the average triglyceride levels of patients in the test was 253 mg/dl. Which is decidedly at the lower levels of the high scale for triglycerides (200 mg/dl -500 mg/dl).
Vascepa approval was for very high range > 500 mg/dl. in the MARINE trial for triglycerides it achieved 27% reduction from baseline. In the MTND trial MAT9001 showed 33% from baseline vs. 10.5% for Vascepa even though Vascepa had a similar percentage in HDL and a much, much better percentage in LDL.
Something seems a little fishy.
MAT9001 results
Vascepa results
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