Oral Brilacidin: tissue to plasma ratio in colon:
Post# of 72445
(Total Views: 499)
Posted On: 12/05/2019 11:52:21 PM
Oral Brilacidin: tissue to plasma ratio in colon: IPIX Brilacidin-UC vs Theravance Biopharma TD1473
Can anyone here line up a comparison of the tissue to plasma ratio in the colon
for Brilacidin vs TD-1473 from the 2 hyperlinked sources I provide?
The following discusses oral brilacidin tested in rats.
https://patents.google.com/patent/US20160243117A1/en
From the link above read figure 12 the image from Oral Brilacidin dosage studied preclinical in rats
[0037]
FIG. 12 illustrates that when PMX-30063 was evaluated for plasma and small intestine concentration following 10 mg/kg given orally or 5 mg/kg given IV in male Balb/c mice (Study 16009-12001), after PO administration, the peak concentration in the small intestine tissue was 38,941 ng per gram of tissue .
Next, the doc for TD-1473 is found by.......
google "theravance tissue to plasma" and the top result yielded should be
[RTF] theravance biopharma, inc. - Investor Relations
(you have to click on this above google result (line above - I bolded it) and it takes you to an SEC doc that shows some Theravance results in rats for colon activity of TD-1473
Next, when in this SEC doc, read under the title
Disposition of TD-1473 in Rat
The Upper and Lower GI Baragraphs compares TD-1473 with tofacitinib in regards to tissue to plasma ratios and content to plasma ratios.
Can any Gastro doctors out there make heads/tails for an intestine tissue concentration comparison of IPIX oral brilacidin in rats to the TD-1473 rats data from Theravance Biopharma???
Can anyone here line up a comparison of the tissue to plasma ratio in the colon
for Brilacidin vs TD-1473 from the 2 hyperlinked sources I provide?
The following discusses oral brilacidin tested in rats.
https://patents.google.com/patent/US20160243117A1/en
From the link above read figure 12 the image from Oral Brilacidin dosage studied preclinical in rats
[0037]
FIG. 12 illustrates that when PMX-30063 was evaluated for plasma and small intestine concentration following 10 mg/kg given orally or 5 mg/kg given IV in male Balb/c mice (Study 16009-12001), after PO administration, the peak concentration in the small intestine tissue was 38,941 ng per gram of tissue .
Next, the doc for TD-1473 is found by.......
google "theravance tissue to plasma" and the top result yielded should be
[RTF] theravance biopharma, inc. - Investor Relations
(you have to click on this above google result (line above - I bolded it) and it takes you to an SEC doc that shows some Theravance results in rats for colon activity of TD-1473
Next, when in this SEC doc, read under the title
Disposition of TD-1473 in Rat
The Upper and Lower GI Baragraphs compares TD-1473 with tofacitinib in regards to tissue to plasma ratios and content to plasma ratios.
Can any Gastro doctors out there make heads/tails for an intestine tissue concentration comparison of IPIX oral brilacidin in rats to the TD-1473 rats data from Theravance Biopharma???
(2)
(0)