Do you, or anyone else, know what is the lowest nu

Do you, or anyone else, know what is the lowest number of patients in trials that has been acceptable for the FDA to approve? I'm genuinely curious about this. This could be a bit of a different animal with the mountain of safety data from the HIV trials, but I want to have a REALISTIC opinion of what the best case scenario is for minimum number of patients and the time it will take.
Thanks