Dose escalation - yes, even in P2 since the origin
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Dose escalation - yes, even in P2 since the original P1 didn't include it - should have been settled long before we even got to P3.
They did a dose escalation in p1, it maxed out at 350mg. The original company screwed that up, with some really big names in hiv attached, which if they had realized they could go all the way to 700mg, we wouldn't be here.