Mention for CYDY in Wikipedia in mTNBC https://
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Posted On: 11/25/2019 1:44:02 PM
Mention for CYDY in Wikipedia in mTNBC
https://en.m.wikipedia.org/wiki/Triple-negati...ast_cancer
https://en.m.wikipedia.org/wiki/Triple-negati...ast_cancer
Quote:
In 2019, CytoDyn initiated a Phase 1b/2 trial with its humanized monoclonal antibody, leronlimab (PRO 140), in combination with chemotherapy following strong results in animal murine models. Among other mechanisms of action, leronlimab is believed to inhibit metastasis by inhibiting the CCR5 receptor on cell surfaces, which is commonly expressed in triple-negative breast cancer. On November 11, 2019, CytoDyn reported that the first TNBC patient injected under its naïve protocol (not previously treated for triple-negative breast cancer) demonstrated significantly reduced levels of circulating tumor cells (CTCs) and decreased tumor size at two-week and five-week observation intervals compared to baseline observations. CTCs are a potential surrogate endpoint in oncology trials, with reduced levels suggesting long-term clinical benefit.[22][23]
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