Some research leading up to this Sacha result usin
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Posted On: 10/17/2019 5:16:55 AM
Some research leading up to this Sacha result using leronlimab we are expecting to be announced soon. I suspect, just guessing, there is no delta32 equivalent mutation, that developed in humans, in the monkeys. So they couldn’t replicate the procedure in humans, but the team came up with the idea, what if we use leronlimab to simulate a delta32 mutation.
2014 attempt to cure monkeys of shiv and issues they faced on transplant
https://www.sciencedaily.com/releases/2014/09...141220.htm
2017 Sacha paper with successful stem cell transplant in monkeys
https://www.nature.com/articles/s41467-017-01631-z
Description of 2017 paper
https://www.sciencedaily.com/releases/2017/11...084315.htm
Researchers have a new way to understand the much-studied Berlin patient's unexpected cure from HIV and improve outcomes of stem cell transplants for patients with other blood-related diseases such as leukemia and sickle-cell disease. A team has shown a species of monkey called Mauritian cynomolgus macaques can successfully receive stem cell transplants.
A decade ago, the medical world was shocked when a patient in Berlin, Germany, had been declared free of HIV after receiving a stem cell transplant to treat cancer. Doctors have repeatedly tried to replicate the result, but this HIV cure has evaded other patients so far.
Dr. Jonah Sacha and colleagues at OHSU's Vaccine & Gene Therapy Institute are among the many scientists who are seeking to understand why the much-studied "Berlin patient" was so fortunate. Now, they've developed a new way to understand his cure. Sacha's team has shown a species of monkey called Mauritian cynomolgus macaques can successfully receive stem cell transplants.
Researchers have long used a different monkey species to research stem cell transplants, but that species' biological characteristics means it can't be reliably used to find good donor matches to mimic human stem transplants.
In a paper published Nov. 10 in the journal Nature Communications, Sacha and colleagues report they successfully performed stem transplants on two monkeys more than a year ago that continue to lead healthy lives today. The recipients did not suffer from the many common adverse effects of stem transplants, including the grueling graft-versus-host disease, which can cause severe liver damage, rashes, diarrhea and even death.
The finding provides Sacha a critical tool needed to explore how the Berlin patient was cured. As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood-related conditions such as leukemia and sickle-cell disease.
Another article in dec 2017 talking about what they did, https://www.amfar.org/monkey-model/
2014 attempt to cure monkeys of shiv and issues they faced on transplant
https://www.sciencedaily.com/releases/2014/09...141220.htm
2017 Sacha paper with successful stem cell transplant in monkeys
https://www.nature.com/articles/s41467-017-01631-z
Description of 2017 paper
https://www.sciencedaily.com/releases/2017/11...084315.htm
Researchers have a new way to understand the much-studied Berlin patient's unexpected cure from HIV and improve outcomes of stem cell transplants for patients with other blood-related diseases such as leukemia and sickle-cell disease. A team has shown a species of monkey called Mauritian cynomolgus macaques can successfully receive stem cell transplants.
A decade ago, the medical world was shocked when a patient in Berlin, Germany, had been declared free of HIV after receiving a stem cell transplant to treat cancer. Doctors have repeatedly tried to replicate the result, but this HIV cure has evaded other patients so far.
Dr. Jonah Sacha and colleagues at OHSU's Vaccine & Gene Therapy Institute are among the many scientists who are seeking to understand why the much-studied "Berlin patient" was so fortunate. Now, they've developed a new way to understand his cure. Sacha's team has shown a species of monkey called Mauritian cynomolgus macaques can successfully receive stem cell transplants.
Researchers have long used a different monkey species to research stem cell transplants, but that species' biological characteristics means it can't be reliably used to find good donor matches to mimic human stem transplants.
In a paper published Nov. 10 in the journal Nature Communications, Sacha and colleagues report they successfully performed stem transplants on two monkeys more than a year ago that continue to lead healthy lives today. The recipients did not suffer from the many common adverse effects of stem transplants, including the grueling graft-versus-host disease, which can cause severe liver damage, rashes, diarrhea and even death.
The finding provides Sacha a critical tool needed to explore how the Berlin patient was cured. As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood-related conditions such as leukemia and sickle-cell disease.
Another article in dec 2017 talking about what they did, https://www.amfar.org/monkey-model/
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