Leronlimab downregulates IFN -gamma and therefore

Leronlimab downregulates IFN -gamma and therefore limits production of PDL-1. I have not found to what extent it limits PDL-1. If leronlimab is very effective against PDL-1 production, Keytruda may be irrelevant.

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However, while release of IFN-gamma by T lymphocytes (CD8+ T cell in particular) is one of the main mechanisms supporting the tumor environmental upregulation of PD-L1, liver metastasis-infiltrating T cells produce CCL5 but no IFN-gamma

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https://www.cell.com/cancer-cell/pdf/S1535-61...0102-7.pdf