Even the most safe medicine we might develop some

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Even the most safe medicine we might develop some problem with , as a rule dose should be as low we need to produce the best results ..

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I agree, I see that as a bullish move by the FDA. They have no issues with the safety, they feel they can squeeze out better efficacy below 10 weeks with 700mg, and they are not concerned with the additional safety problems that brings, even though 525mg should already be exceptional with combo (given 325mg was at 81%).