Either those blips cause a fall in CD4 cell counts or a drop in the CD4 cell counts may be the cause. Most likely it's a circular path that feeds off each other. Either way a lower CD4 count can cause untold problems. The HIV drugs I took a quick look at seemed to have an increased CD4 count between 50-100 c/ml, leronlimab's is 200+ c/ml.
Quote:The most surprising finding over recent years, however, has been reports that several clinical outcomes previously thought to be unrelated to HIV infection are more common in those with low CD4 cell counts. Data from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A) Study suggest that the risk of mortality from several non-AIDS causes is increased at lower CD4 cell counts, including deaths from liver-related causes. In the SMART trial, patients randomized to interrupted treatment had a higher risk of major cardiovascular, renal, and hepatic disease than those
randomized to continued treatment, suggesting an impact of HIV on these events (although a possible impact of prior treatment followed by discontinuation cannot be ruled out). In the CPCRA FIRST study , each doubling in the latest CD4 cell count was associated with a 20% reduction in the risk of non-AIDS diseases, with similar associations noted between the latest CD4 cell count and renal, cardiovascular, and non-AIDS cancer events. The EuroSIDA study has reported that both pancreatitis and chronic renal failure were less common in those with higher CD4 cell counts.
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