To go with bigger injection , like now 525 mg in o

To go with bigger injection , like now 525 mg in one injection , no safety data needed , at the end just every physician can change that , some patients may not tolerate and will need two injection, no need for FDA.

To change the dose , yes ,
In practice we sometimes go with higher than recommended dose at the beginning , but officially recommend , I am almost 100% sure must have official safety data...