CCR5 , Cancers , Leronlimab.... 1.) CCR5 make

CCR5 , Cancers , Leronlimab....


1.) CCR5 makes cancers cells metastasize ...

........A.) By calcium channel signalling on CCR5 on cancer cells , witch is important to produce metastasis.
........B.) CCR5 makes tumors more aggressive , CCR5 center cells cluster together in a different way witch enables the cancer cells to metastasize ...(Thank you Trding).
.........C. ) once cancer cells enter to bloodstream and ( and thus become ) CTC, being CCR5 + guides them to the most dangerous and deadly possible sites : Brain , bones , other organs , ..(.Thank you Trding.)

Leronlimab block all this...
Papers:

https://content.equisolve.net/_5dde3bf0adc368...breast.pdf

https://content.equisolve.net/_5dde3bf0adc368...review.pdf

https://content.equisolve.net/_5dde3bf0adc368...ostate.pdf

https://cancerres.aacrjournals.org/content/ca...7.full.pdf




2.) CCR5 activates DNA mechanism....

...........cancer cells recuperate much faster after chemotherapy , becoming resistant to treatment ,

Leronlimab is blocking that.

Papers:
https://content.equisolve.net/_5dde3bf0adc368...R.full.pdf
https://www.cell.com/stem-cell-reports/pdf/S2...0145-6.pdf

3.) Regulate body anti-tumor response ..

...........A. ) there is polarization of macrophages with CCR5 inhibitors.
process by witch macrophages adopt different functional programs..

M0--uncommitted macrophages ..
M1--classically activated , produce pro-inflammatory process and irritation of immune system , important in the host defense against pathogens .
M2--alternatively activated, turning on constructive process, like wound healing , producing anti-inflammatory cytokines.
And all this help to produce necrosis of tumors.

............B. ) From Dr Patterson we also know that CCR5 is expressed on the population of immune cells call T regulatory cells witch inhibits response to cancers .

Papers:
https://www.cell.com/cancer-cell/pdf/S1535-61...0102-7.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...-01477.pdf
https://www.frontiersin.org/articles/10.3389/...02629/full

4.) Leronlimab inhibits angiogenesis

Recently we also learned from Dr Lindner pre-clinical study in colon cancer that Leronlimab inhibits angiogenesis , and is working on solid tumors with both high and low CCR5 expression..

Papers:
https://www.ncbi.nlm.nih.gov/pubmed/25330803
https://academic.oup.com/carcin/article/36/1/104/376718
https://www.cell.com/stem-cell-reports/pdf/S2...0145-6.pdf
https://www.cytodyn.com/newsroom/press-releas...of-ccr5-in


5) CCR5 Promotes Cancer Recurrance

Paper:
https://elifesciences.org/articles/43653

Node-Negative Overall Survival with ccr5 from Pestell paper Figure 1B
https://content.equisolve.net/_5dde3bf0adc368...R.full.pdf