CCR5 , Cancers , Leronlimab.... 1.) CCR5 make
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Posted On: 08/10/2019 7:20:54 PM
CCR5 , Cancers , Leronlimab....
1.) CCR5 makes cancers cells metastasize ...
........A.) By calcium channel signalling on CCR5 on cancer cells , witch is important to produce metastasis.
........B.) CCR5 makes tumors more aggressive , CCR5 center cells cluster together in a different way witch enables the cancer cells to metastasize ...(Thank you Trding).
.........C. ) once cancer cells enter to bloodstream and ( and thus become ) CTC, being CCR5 + guides them to the most dangerous and deadly possible sites : Brain , bones , other organs , ..(.Thank you Trding.)
Leronlimab block all this...
Papers:
https://content.equisolve.net/_5dde3bf0adc368...breast.pdf
https://content.equisolve.net/_5dde3bf0adc368...review.pdf
https://content.equisolve.net/_5dde3bf0adc368...ostate.pdf
https://cancerres.aacrjournals.org/content/ca...7.full.pdf
2.) CCR5 activates DNA mechanism....
...........cancer cells recuperate much faster after chemotherapy , becoming resistant to treatment ,
Leronlimab is blocking that.
Papers:
https://content.equisolve.net/_5dde3bf0adc368...R.full.pdf
https://www.cell.com/stem-cell-reports/pdf/S2...0145-6.pdf
3.) Regulate body anti-tumor response ..
...........A. ) there is polarization of macrophages with CCR5 inhibitors.
process by witch macrophages adopt different functional programs..
M0--uncommitted macrophages ..
M1--classically activated , produce pro-inflammatory process and irritation of immune system , important in the host defense against pathogens .
M2--alternatively activated, turning on constructive process, like wound healing , producing anti-inflammatory cytokines.
And all this help to produce necrosis of tumors.
............B. ) From Dr Patterson we also know that CCR5 is expressed on the population of immune cells call T regulatory cells witch inhibits response to cancers .
Papers:
https://www.cell.com/cancer-cell/pdf/S1535-61...0102-7.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...-01477.pdf
https://www.frontiersin.org/articles/10.3389/...02629/full
4.) Leronlimab inhibits angiogenesis
Recently we also learned from Dr Lindner pre-clinical study in colon cancer that Leronlimab inhibits angiogenesis , and is working on solid tumors with both high and low CCR5 expression..
Papers:
https://www.ncbi.nlm.nih.gov/pubmed/25330803
https://academic.oup.com/carcin/article/36/1/104/376718
https://www.cell.com/stem-cell-reports/pdf/S2...0145-6.pdf
https://www.cytodyn.com/newsroom/press-releas...of-ccr5-in
5) CCR5 Promotes Cancer Recurrance
Paper:
https://elifesciences.org/articles/43653
Node-Negative Overall Survival with ccr5 from Pestell paper Figure 1B
https://content.equisolve.net/_5dde3bf0adc368...R.full.pdf
1.) CCR5 makes cancers cells metastasize ...
........A.) By calcium channel signalling on CCR5 on cancer cells , witch is important to produce metastasis.
........B.) CCR5 makes tumors more aggressive , CCR5 center cells cluster together in a different way witch enables the cancer cells to metastasize ...(Thank you Trding).
.........C. ) once cancer cells enter to bloodstream and ( and thus become ) CTC, being CCR5 + guides them to the most dangerous and deadly possible sites : Brain , bones , other organs , ..(.Thank you Trding.)
Leronlimab block all this...
Papers:
https://content.equisolve.net/_5dde3bf0adc368...breast.pdf
https://content.equisolve.net/_5dde3bf0adc368...review.pdf
https://content.equisolve.net/_5dde3bf0adc368...ostate.pdf
https://cancerres.aacrjournals.org/content/ca...7.full.pdf
2.) CCR5 activates DNA mechanism....
...........cancer cells recuperate much faster after chemotherapy , becoming resistant to treatment ,
Leronlimab is blocking that.
Papers:
https://content.equisolve.net/_5dde3bf0adc368...R.full.pdf
https://www.cell.com/stem-cell-reports/pdf/S2...0145-6.pdf
3.) Regulate body anti-tumor response ..
...........A. ) there is polarization of macrophages with CCR5 inhibitors.
process by witch macrophages adopt different functional programs..
M0--uncommitted macrophages ..
M1--classically activated , produce pro-inflammatory process and irritation of immune system , important in the host defense against pathogens .
M2--alternatively activated, turning on constructive process, like wound healing , producing anti-inflammatory cytokines.
And all this help to produce necrosis of tumors.
............B. ) From Dr Patterson we also know that CCR5 is expressed on the population of immune cells call T regulatory cells witch inhibits response to cancers .
Papers:
https://www.cell.com/cancer-cell/pdf/S1535-61...0102-7.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...-01477.pdf
https://www.frontiersin.org/articles/10.3389/...02629/full
4.) Leronlimab inhibits angiogenesis
Recently we also learned from Dr Lindner pre-clinical study in colon cancer that Leronlimab inhibits angiogenesis , and is working on solid tumors with both high and low CCR5 expression..
Papers:
https://www.ncbi.nlm.nih.gov/pubmed/25330803
https://academic.oup.com/carcin/article/36/1/104/376718
https://www.cell.com/stem-cell-reports/pdf/S2...0145-6.pdf
https://www.cytodyn.com/newsroom/press-releas...of-ccr5-in
5) CCR5 Promotes Cancer Recurrance
Paper:
https://elifesciences.org/articles/43653
Node-Negative Overall Survival with ccr5 from Pestell paper Figure 1B
https://content.equisolve.net/_5dde3bf0adc368...R.full.pdf
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