One other item Lalezari said was of interest to me

One other item Lalezari said was of interest to me, it is hard to find metastatic patients in the naive setting. I am trying to find the percent of tnbc that are first diagnosed at stage 4. So far I can’t find any statistics on stage breakdown at first diagnoses. I did find the 5 year survival rate is 77% for overall tnbc, but 22% for metastatic, So most of the majority of first diagnosed tnbc patients must be stage 3 or less. Could be the big issue. Also giveb that only 3-5% are usually interested in clinical trials, and you could have a small number of potential patients. That is why they need the big sites on it.

The American Cancer Society report the following 5-year survival rates for breast cancer:

stage 0 to 1 — near 100 percent survival rate
stage 2 — about 93 percent survival rate
stage 3 — 72 percent survival rate
stage 4 (metastatic) — 22 percent survival rate