CCR5 , Cancers , Leronlimab.... 1.) CCR5 make

CCR5 , Cancers , Leronlimab....


1.) CCR5 makes cancers cells metastasize ...

........A.) By calcium channel signalling on CCR5 on cancer cells , witch is important to produce metastasis.
........B.) CCR5 makes tumors more aggressive , CCR5 center cells cluster together in a different way witch enables the cancer cells to metastasize ...(Thank you Trding).
.........C. ) once cancer cells enter to bloodstream and ( and thus become ) CTC, being CCR5 + guides them to the most dangerous and deadly possible sites : Brain , bones , other organs , ..(.Thank you Trding.)

Leronlimab block all this...

2.) CCR5 activates DNA mechanism....

...........cancer cells recuperate much faster after chemotherapy , becoming resistant to treatment ,

Leronlimab is blocking that.

3.) Regulate body anti-tumor response ..

...........A. ) there is polarization of macrophages with CCR5 inhibitors.
process by witch macrophages adopt different functional programs..

M0--uncommitted macrophages ..
M1--classically activated , produce pro-inflammatory process and irritation of immune system , important in the host defense against pathogens .
M2--alternatively activated, turning on constructive process, like wound healing , producing anti-inflammatory cytokines.
And all this help to produce necrosis of tumors.

............B. ) From Dr Patterson we also know that CCR5 is expressed on the population of immune cells call T regulatory cells witch inhibits response to cancers .


4.) Recently we also learned from Dr Lindner pre-clinical study in colon cancer that Leronlimab inhibits angiogenesis , and is working on solid tumors with both high and low CCR5 expression..