Awhile back I posted about how leronlimab may act
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Posted On: 08/09/2019 12:30:28 AM
Awhile back I posted about how leronlimab may act as a cure taken long term. Reservoir cells are very long lasting and seem to be triggered to release HIV when the HIV level drops very, very low. Leronlimab can cover any CCR5 receptors so any released HIV can't infect new cells. Given the half life of reservoir cells I think I estimated reservoir cells would be exhausted of HIV in 7 years. Which is why I was interested in HIV levels of patients that have been on leronlimab 5 years.
With stem cell transplants I don't see how they can get around either radiation or chemotherapy. Without the destruction of the original bone marrow I don't see how HIV blocking stem cells can fully supplant bone marrow producing cells that produce HIV attachable cells. If chemo or radiation is used then I don't see why leronlimab would be necessary except to initially lower HIV levels.
The plus side vs. CCR5 delta 32 stem cell implantation is one's own stem cells could be used which would eliminate rejection issues.
With stem cell transplants I don't see how they can get around either radiation or chemotherapy. Without the destruction of the original bone marrow I don't see how HIV blocking stem cells can fully supplant bone marrow producing cells that produce HIV attachable cells. If chemo or radiation is used then I don't see why leronlimab would be necessary except to initially lower HIV levels.
The plus side vs. CCR5 delta 32 stem cell implantation is one's own stem cells could be used which would eliminate rejection issues.
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