As to the dose of the emergency IND, Marek wrote:
Post# of 148316
"Sorry for the delayed response. And, thank you for writing. The dose is patient determined by Dr. Lalezari. He drives the boat on this one. We're all just anxious and very interested passengers. We haven't disclosed the dosing. But, I assume it is just like with any other drug. Titrated to match desired blood concentrations given the patient's body mass and estimated tumor burden."
Seems to me like they could start with a higher dose when necessary, given a high tumour burden.