A humanized anti-VLA-4 mAb (‘Natalizumab’) tha
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Posted On: 08/01/2019 9:19:50 PM
A humanized anti-VLA-4 mAb (‘Natalizumab’) that managed to reach the clinic was found effective in relapsing-remitting multiple sclerosis,208,209 and was approved for this indication. The most likely mode of action is inhibition of crossing the blood–brain barrier by activated T cells and dendritic cells.
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