Yes, so many roles Ccr5 plays in cancer’s goal

Yes, so many roles Ccr5 plays in cancer’s goal metastasis. In addition to these below by Pestell, blocking Ccr5 turns MAMs from cancer promoting to cancer killing. I suspect this latest find is yet another new Ccr5 connection we will find.


https://s3.amazonaws.com/content.stockpr.com/...R.full.pdf

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First, human breast cancer and breast cancer cell lines were shown to express CCR5 with expression patterns that are heterogeneous within the tumor, and higher cytoplasmic CCR5 staining correlated with poor prognosis. Second, the 1668 Cancer Res; 78(7) April 1, 2018
CCR5þ-expressing human breast cancer cells within the tumor initiate tumors in mice that grow approximately 60-fold larger than CCR5 cells. Third, CCR5 antagonists reduced the ability of basal breast cancer cells to metastasize. Fourth, CCR5 expression correlated with the ability of breast cancer cells to form mammospheres, a surrogate assay for tumor-initiating cells. Fifth, functional analysis demonstrated endogenous CCR5 enhanced DNA repair (HDR and SSA) in response to DNA-damaging agents used in chemotherapy for breast cancer and enhanced repair in response to high dose g -irradiation and unbiased gene expression analysis of CCR5þ cells demonstrated enrichment of pathways governing DNA damage and DNA repair. Consequently, CCR5 antagonists substantially enhanced the cell killing of diverse human breast cancer cell lines in response to DNA damage– inducing chemotherapy.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243037/