Interesting find with cancer, tumors recruit brain
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Posted On: 07/18/2019 4:16:21 AM
Interesting find with cancer, tumors recruit brain cells from the subventricular zone, see link below. These cells show up in many cancers and the more, the more aggressive and more metastasis. They have not figured out how they get from the brain to the tumor.
So my first thought was there is ccr5 connection linking the metastasis and possible movement of these cells.
Found this article.
https://www.sciencedirect.com/science/article...4003013181
In summary, we have shown for the first time that NPCs isolated from the SVZ of the adult rat brain express chemokine receptors CXCR4, CCR2, CCR5 , and CX3CR1. These data suggest that chemokine receptors might play roles in the regulation of adult NPCs in the physiological or pathological conditions.
https://massivesci.com/articles/neurons-migra...treatment/
Looking at these areas in the prostate cancer mouse model, the authors saw that these cells in the SVZ—but not anywhere else in the brain—decreased throughout cancer progression. When the scientists started tracking the SVZ during cancer development in mice, they realized that the neural progenitor cells actually left the brain, migrated through the blood, and infiltrated the tumor!
studying these neurons and how they infiltrate tumors may provide keys for how to better monitor, predict, and potentially treat cancer.
So my first thought was there is ccr5 connection linking the metastasis and possible movement of these cells.
Found this article.
https://www.sciencedirect.com/science/article...4003013181
In summary, we have shown for the first time that NPCs isolated from the SVZ of the adult rat brain express chemokine receptors CXCR4, CCR2, CCR5 , and CX3CR1. These data suggest that chemokine receptors might play roles in the regulation of adult NPCs in the physiological or pathological conditions.
https://massivesci.com/articles/neurons-migra...treatment/
Looking at these areas in the prostate cancer mouse model, the authors saw that these cells in the SVZ—but not anywhere else in the brain—decreased throughout cancer progression. When the scientists started tracking the SVZ during cancer development in mice, they realized that the neural progenitor cells actually left the brain, migrated through the blood, and infiltrated the tumor!
studying these neurons and how they infiltrate tumors may provide keys for how to better monitor, predict, and potentially treat cancer.
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