Yes, they got some good results from biopsy less t

Yes, they got some good results from biopsy less than 2 weeks in, see Fig 5D. We could get good results as early as 21 days in, seeing the ctc go below 5 is all it would take to convince me (and I'm sure some other shareholders). The 84 day estimate was the earliest estimate to convince the FDA to apply for breakthrough designation.

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Patients received 300 mg of maraviroc twice daily with a pre-treatment biopsy and a second biopsy of the same liver metastasis after treatment for 8–10 days (Figure 5A). Observed clinical effects include induction of central tumor necrosis (Figure 5B) and a partial remission of lung metastases (Figures 5C and S5A) In a patient with malignant pleural effusions, the reduction of MIF and hepatocyte growth factor (HGF) seen in the explant models was recapitulated within the effusion (Figure S5B), highlighting the systemic effects of maraviroc. On a histological level, all tumor samples showed reduced proliferation (as evidenced by Ki67 staining, Figure S5C) and increased tumor cell death as evidenced by morphology (Figure 5D), while the morphology of the adjacent normal liver was unchanged (Figure 5D). Moreover, the effects on the microenvironment induced by maraviroc as seen in the short-term explant models could also be observed in the patient biopsies. Marked reductions in key cytokines and growth factors promoting tumor growth, chemotherapy resistance, or angiogenesis were seen in most clinical samples

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