Here is one showing it can block ccl5. https://
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Posted On: 06/10/2019 12:12:13 PM
Here is one showing it can block ccl5.
https://jvi.asm.org/content/jvi/73/5/4145.full.pdf
Here is way way back when pro 140 was called PA14. They had several Mabs testing and they where looking for one that blocked hiv, but not interfere with the chemokines.
It does block ccl5, as the dose reaches a certain point, it escalates quickly. In the perfect world, 525mg would mildly inhibit ccl5 used for HIV (with less side-effects), and 700mg used for cancer inhibits ccl5 but still allows mip1-a and mip-1b to function.
https://jvi.asm.org/content/jvi/73/5/4145.full.pdf
Here is way way back when pro 140 was called PA14. They had several Mabs testing and they where looking for one that blocked hiv, but not interfere with the chemokines.
Quote:
CCR5 is able to bind three CC-chemokines, RANTES, MIP-1a, and MIP-1b, and transduce a signal that modulates cyto-solic calcium levels.
Quote:
Compared with 2D7, PA14 is equipotent atinhibiting HIV-1 fusion and entry but 10-fold less potent atinhibiting RANTES-induced signaling.
It does block ccl5, as the dose reaches a certain point, it escalates quickly. In the perfect world, 525mg would mildly inhibit ccl5 used for HIV (with less side-effects), and 700mg used for cancer inhibits ccl5 but still allows mip1-a and mip-1b to function.
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