Not sure if this is complete explanation. Yes , w
Post# of 154115
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Posted On: 06/04/2019 7:06:10 AM
Not sure if this is complete explanation.
Yes , would be interesting to see what happening with CD8 T cells in CCR5 delta32,
but then why so selective sensitivities , only few diseases , like more problem with flu virus ,
And why patients on Leronlimab VL going up when they have flu...
It will be interesting to do preclinical studies with Leronlimab and few of this diseases ...
We still need many answers , but good thing is that Leronlimab is not changing CCR5 permanently ...and is use for severe diseases with much shorter life expectation, and so far we don't see problems .
Hopefully because it selectively blocs CCR5 without changes of other immune systems function , but I am not sure if this is entire explanation...
In following diseases :
-HIV short life without treatment,
-With HAART , shorter due to many factors like due to high lipids than heart problems , organ damage , severe osteoporosis and others ,
- GvHD , often deadly without treatment
-and with cancers if we could add 10-20 or more quality years to people with survival for few years otherwise , this is great.
But many things need to be answer for us to know for sure...
IMO only.
Yes , would be interesting to see what happening with CD8 T cells in CCR5 delta32,
but then why so selective sensitivities , only few diseases , like more problem with flu virus ,
And why patients on Leronlimab VL going up when they have flu...
It will be interesting to do preclinical studies with Leronlimab and few of this diseases ...
We still need many answers , but good thing is that Leronlimab is not changing CCR5 permanently ...and is use for severe diseases with much shorter life expectation, and so far we don't see problems .
Hopefully because it selectively blocs CCR5 without changes of other immune systems function , but I am not sure if this is entire explanation...
In following diseases :
-HIV short life without treatment,
-With HAART , shorter due to many factors like due to high lipids than heart problems , organ damage , severe osteoporosis and others ,
- GvHD , often deadly without treatment
-and with cancers if we could add 10-20 or more quality years to people with survival for few years otherwise , this is great.
But many things need to be answer for us to know for sure...
IMO only.
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