"This paper and the following two below sparked a
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Posted On: 06/01/2019 2:02:01 PM
"This paper and the following two below sparked a new research idea, just published, what if you want the opposite to occur, where ccr5/ccl5 could be used as therapeutic to promote cell survival following for example irradiation injury."
CCL5 and the overexpression of CCR5 add to the likelihood of cancer development.
"CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells"
One of the hallmarks of tumor growth is a massive network of blood vessels. The last thing you want is promotion of angiogenesis.
In a paper I read a while back (with Dr. Pestell being one of the co-authors) they explain that CCR5 may aid in cancer stem cells being able to repair their DNA even after chemotherapy or radiation therapy.
CCL5/CCR5 bad
In fact I would go so far as to say anyone hit with an accidental radiation exposure or undergoing radiation therapy would highly benefit by taking a CCR5 blocker like leronlimab.
CCL5 and the overexpression of CCR5 add to the likelihood of cancer development.
"CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells"
One of the hallmarks of tumor growth is a massive network of blood vessels. The last thing you want is promotion of angiogenesis.
In a paper I read a while back (with Dr. Pestell being one of the co-authors) they explain that CCR5 may aid in cancer stem cells being able to repair their DNA even after chemotherapy or radiation therapy.
CCL5/CCR5 bad
In fact I would go so far as to say anyone hit with an accidental radiation exposure or undergoing radiation therapy would highly benefit by taking a CCR5 blocker like leronlimab.
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