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Yeah, the standard treatment with most ccr5+ cance

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Post# of 155138
(Total Views: 359)
Posted On: 05/30/2019 4:12:42 PM
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Posted By: trding
Re: misiu143 #3688
Yeah, the standard treatment with most ccr5+ cancers will probably be chemo + leronlimab. I was just talking about mTnbc. I have been searching for mouse models with approved drugs to see if any hit 98% reduction in tumor burden. It is hard to find results like we have announced, but I will continue to look.

I looked up the line they used in colon study listed in the PR.

Quote:
The SW480 cell line was derived from a patient with colon adenocarcinoma and, like many human cancers, was CCR5-positive.



https://www.atcc.org/en/Products/All/CCL-228.aspx
https://www.sigmaaldrich.com/catalog/product/...;region=US


The patient had Dukes' type B, colorectal adenocarcinoma

The initial cultures contained a mixture of epithelial and bipolar cells, but subsequently epithelial cells predominated. The cells produce CEA.



https://www.cancer.gov/publications/dictionar...tal-cancer

Quote:
Dukes B colorectal cancer

Cancer has spread (1) through the muscle layer of the colon and/or rectal wall to the serosa (outermost layer) of the colon and/or rectal wall; or (2) through the serosa of the colon and/or rectal wall but has not spread to nearby organs; or (3) through the serosa of the colon and/or rectal wall to nearby organs. Also called stage II colorectal cancer.



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