CCR5 connection to most common cancers A work in

New Post Public Reply Private Reply Replies (7) Message Board
trding
10,289
CCR5 connection to most common cancers

A work in progress...

Most Common US Cancer Yearly Stats
https://www.cancer.gov/types/common-cancers

Good overall read
https://www.hindawi.com/journals/mi/2014/292376/
The Inflammatory Chemokine CCL5 and Cancer Progression
January 2014

1) Breast Cancer
New Cases: 271k Deaths: 42k

Feb 2019
CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer.
https://www.ncbi.nlm.nih.gov/pubmed/30456574

June 2018
https://breast-cancer-research.biomedcentral....018-0981-3
Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis

Jan 2018
CCR5 governs DNA damage and breast cancer stem cell expansion
http://cancerres.aacrjournals.org/content/ear...AN-17-0915
CCR5 antagonists Maraviroc and Vicriviroc dramatically enhanced cell killing mediated by DNA-damaging chemotherapeutic agents. Single cell analysis revealed CCR5 governs PI3K/Akt, ribosomal biogenesis, and cell survival signaling. As CCR5 augments DNA repair and is re-expressed selectively on cancerous but not normal breast epithelial cells, CCR5 inhibitors may enhance the tumor-specific activities of DDR-based treatments, allowing a dose reduction of standard chemotherapy and radiation.

April 2013
The CCL5/CCR5 axis promotes metastasis in basal breast cancer
https://www.tandfonline.com/doi/full/10.4161/onci.23660

Aug 2012
CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells
cancerres.aacrjournals.org/content/72/15/3839.short

The CCR5 antagonists maraviroc or vicriviroc, developed to block CCR5 HIV coreceptor function, reduced in vitro invasion of basal breast cancer cells without affecting cell proliferation or viability, and maraviroc decreased pulmonary metastasis in a preclinical mouse model of breast cancer.



2) Lung
New Cases: 228k Deaths: 143k

Mar 2019
CCR5 is Associated With Immune Cell Infiltration and Prognosis of Lung Cancer
https://www.jto.org/article/S1556-0864(19)30121-2/fulltext



Feb 2014
Chemokine Receptor 5 on Pulmonary Mesenchymal Cells Promotes Experimental Metastasis via the Induction of Erythroid Differentiation Regulator 1
http://mcr.aacrjournals.org/content/12/2/274

Dec 2012
Deficiency of C–C chemokine receptor 5 suppresses tumor development via inactivation of NF–ĸB and inhibition of monocyte chemoattractant protein-1 in urethane-induced lung tumor model
https://academic.oup.com/carcin/article/33/12/2520/2464119

It was found that a CCR5 inhibitor (TAK-779) reduced regulatory T cells migration to tumors so that tumor growth was smaller than in non-treated control mice


3) Prostate
New Cases: 175k Deaths: 32k



Sept 2005
Expression of CCL5 (RANTES) and CCR5 in prostate cancer
https://onlinelibrary.wiley.com/doi/pdf/10.1002/pros.20306

the CCR5 antagonist TAK779 inhibited CCL5 induced proliferation.


4)Colorectal
New Cases: 146k Deaths: 51k

March 2019
Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5
https://www.nature.com/articles/s41419-019-1508-2
Notably, the CCR5 inhibitor, maraviroc, significantly abolished the MSC-induced tumor growth in vivo. In human clinical specimens (n=89), 20 cases (29%) were high for CCR5, whereas 69 cases (71%) were low

the 5 year survival rate for stage III, IV for colorectal cancer with low ccr5 expression was 70% and the high ccr5 expression just 10%, p value .001.





April 2010
Low expression of chemokine receptor CCR5 in human colorectal cancer correlates with lymphatic dissemination and reduced CD8+ T-cell infiltration
https://link.springer.com/article/10.1007%2Fs...009-0868-y



5) Melanoma

New Cases: 96k Deaths: 7k
Feb 2007
Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma.
https://www.ncbi.nlm.nih.gov/pubmed/17306330
CCR5 was exclusively expressed in primary melanomas and some cutaneous metastases.


2003
Host absence of CCR5 potentiates dendritic cell vaccination.
https://www.ncbi.nlm.nih.gov/pubmed/12682253
we used a murine melanoma system and knockout mice to investigate the function of the chemokine receptor CCR5 and its ligands, CCR ligand (CCL)3 and CCL5. We found that the lack of CCR5 in the host mouse resulted in delayed tumor growth, but this effect was overcome at a higher tumor load.


6) Bladder
New Cases: 80k Deaths: 18k



7)Non-Hodgkin Lymphoma
New Cases: 74k Deaths: 20k

March 2018
High expression of CC chemokine receptor 5 (CCR5) promotes disease progression in patients with B-cell non-Hodgkin lymphomas
https://www.sciencedirect.com/science/article...via%3Dihub


8) Kidney Cancer
New Cases: 74k Deaths: 15k

Mar 2015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467270/
Expression of CC chemokine receptor 5 in clear cell renal cell carcinoma and its clinical significance



9) Endometrial
New Cases: 62k Deaths: 12k

10)Leukemia
New Cases: 62k Deaths: 23k


11) Pancreatic

New Cases: 57k Deaths: 46k
Feb 2009
https://www.ncbi.nlm.nih.gov/pubmed/19155524
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.

Selective targeting of CCR5/CCL5 signaling may represent a novel immunomodulatory strategy for the treatment of cancer.
we have found that the growth of pancreatic adenocarcinoma may be inhibited by CCR5-mediated blockade of Treg migration.

12) Thyroid
New Cases: 52k Deaths: 2k

13) Liver

New Cases: 42k Deaths: 31k


Gastic Cancer
New Cases: 27k Deaths: 11k
Feb 2008
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.23401
Gastric cancer cells exploit CD4+ cell derived CCL5 for their growth and prevention of CD8+ cell involved tumor elimination

They did mouse models also with antagonist, 6 week all the mice died without the antagonist, 95% lived with.

Hodgkin Lymphoma
New Cases: 8k Deaths: 1k
Mar 2019
CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth
http://www.haematologica.org/content/104/3/564



Oct 2007
Expression of CCR5 receptors on Reed–Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.23119

CytoDyn Inc (CYDY) Stock Research Links

CYDY Board Company Profile Buy Rating Time & Sales News Filings Financials
Scroll down for more posts ▼

Top 10 Most Recent News Articles

Regeneron Faces Legal Heat: Lead Plaintiff Deadline Looms

Updated Category News Views 6

Regeneron’s Tight Spot: Legal Showdown Well, here we go again—Regeneron Pharmaceuticals (NASDAQ:REGN) is under some serious heat. If you're an investor who faced significant losses with this biotech juggernaut, remember that the clock’s ticking down to the wire. By tomorrow, September 14, 2026, you need to decide if you're going to throw your hat in the ring for...

Continue Reading
GORGIE Unleashes Berry Burst: Target's New Drink Star

Updated Category News Views 6

GORGIE Targets Taste Buds with Berry Burst Ever feel like you're missing out on that energy drink everyone seems to be raving about? Well, GORGIE's out there making some noise again, and this time it's got a new punchy player in the game: Berry Burst. It's not just another drink; it's shaking things up in the energy aisle with its exclusive launch at Target. Modern style...

Continue Reading
PANDAG G1 Debuts: Revolutionizing Lawn Care Efficiency

Updated Category News Views 6

The Future of Landscaping Unveiled Get this—PANDAG is set to shake things up at GaLaBau 2026 with their futuristic G1 autonomous mower. This isn't just another piece of lawn equipment; it's practically a tech marvel on wheels, weaving together LiDAR, AI Vision, RTK, and 4G tech to make it the ultimate multitasker for the landscaping industry. We're talking obstacle...

Continue Reading
Surfing Dogs Ride Waves, Support Orphan Pets

Updated Category News Views 3

Waves, Paws, and Passion Who would've thought that dogs catching waves could also catch hearts and wallets? Well, that's exactly what's happening today at Del Mar Dog Beach with the 21st Annual Surf Dog Surf-A-Thon revving up the excitement. It's a sun-soaked day in Rancho Santa Fe, California, right in the thick of things at the longest-running dog surf competition. For...

Continue Reading
Ris-Rez May Set New Standard in Relapsed SCLC

Updated Category News Views 7

The Game-Changing Results Innovation in pharmaceuticals sometimes feels like a waiting game, but when a fresh breakthrough like this rolls in, it lights up the whole landscape. Risvutatug rezetecan, or Ris-Rez for short, has shown promising potential in the fight against relapsed small-cell lung cancer (SCLC) that has progressed after platinum-based therapy. Survival...

Continue Reading
MRI Surveillance Gains Ground in Lung Cancer Care

Updated Category News Views 7

Shifting the Standard: MRI's Rise in SCLC Treatment Here's a twist that baffles the traditionalists—ditch the prophylactic cranial irradiation (PCI) and catch clearer days with MRI surveillance for small-cell lung cancer (SCLC). The latest international phase III MAVERICK trial might just redraw the lines on what's considered standard care in this relentless disease....

Continue Reading
Tam-Peli Steps Up in SCLC Battle: Trial Insights

Updated Category News Views 5

Noteworthy Developments in Small-Cell Lung Cancer Treatment Let's dive into a story straight from the world of small-cell lung cancer (SCLC) that doesn't take any prisoners. The antidote making waves is tambotatug pelitecan, or Tam-Peli for short, showcasing its might in the unrelenting fight against relapsed SCLC. The phase III TAISHAN-302 trial puts Tam-Peli...

Continue Reading
First-Time Homeowners: Unseen Pitfalls of Insurance

Updated Category News Views 6

Understanding Homeowners Insurance: Beyond the Basics Most folks diving into homeownership for the first time get caught up in the whirlwind of price tags, loans, and knick-knacks for their new place. Meanwhile, the nitty-gritty of homeowners insurance often gets tossed to the side. But take it from a weary watchdog of financial storms—it’s those details in the policy...

Continue Reading
PwC US and India Unite for Global Consultancy Powerhouse

Updated Category News Views 7

Rearranging the Consultancy Chessboard Piling onto the game of consultancy realignments, PwC just made a move reminiscent of playing strategy poker. They're tossing together PwC US and PwC India's advisory capabilities for a new joint venture. It’s like pushing two puzzle pieces to make a single colorful picture that stretches from the U.S. all the way to the...

Continue Reading
Trial Disappointment: No Significant Gains in NSCLC

Updated Category News Views 21

Dissecting the Nuances of the EVOKE-03/KEYNOTE-D46 Trial Every once in a while, we come across a trial that rattles cages in the research community. Today, it's the EVOKE-03/KEYNOTE-D46 trial, a collision of hope and hard-knock reality. This Phase 3 trial, which sought to explore the potential combo of sacituzumab govitecan (SG) and pembrolizumab on metastatic non-small...

Continue Reading

Top 5 Most Recently Viewed Articles

Nippon Steel and TIER IV Unite for Autonomous Steel Transport

Updated Category News Views 357

Innovative Partnership for Autonomous Steel Transportation Nippon Steel Corporation, known as Japan's largest steel manufacturer, has initiated a significant collaboration with TIER IV, Inc., a trailblazer in the development of open-source software for autonomous driving. This partnership is set to revolutionize the way steel is transported within manufacturing...

Continue Reading
Brock Group Expands Leadership with New Regional Units

Updated Category News Views 303

The Brock Group Expands Leadership with New Regional Units The Brock Group is taking significant strides in enhancing its Brock Industrial Services (BIS) division. Recently, the company announced the creation of two new regional operating units designed to bolster its service capabilities and responsiveness for customers nationwide. Under this new organizational...

Continue Reading
Exploring Demand for Nasdaq-100 Index in Retirement Plans

Updated Category News Views 178

Rising Interest in Nasdaq-100 Index for Retirement Investments Recent findings reveal a burgeoning interest in the Nasdaq-100 Index among retirement plan participants. This trend signifies a noteworthy opportunity for retirement investment options catering to the needs of a modern workforce. A recent survey indicated that nearly 80 percent of 401(k) plan participants...

Continue Reading
ModivCare Securities Lawsuit Update: Key Details for Investors

Updated Category News Views 132

Important Updates Regarding ModivCare Lawsuit Levi & Korsinsky, LLP is reaching out to investors who have been part of ModivCare Inc. (NASDAQ: MODV) regarding a pivotal class action securities lawsuit. This notification signals a chance for investors affected by the Company’s alleged securities fraud to seek compensation. Understanding the Class Action Lawsuit The...

Continue Reading
Key Details for Nordic Fibreboard AS Annual Meeting Announcement

Updated Category News Views 163

Essential Details for the Upcoming Annual General Meeting The Annual General Meeting (AGM) of Nordic Fibreboard AS (registry code: 11421437) will be convened to discuss pivotal matters affecting the company's future. Set to take place at the headquarters in Pärnu, Estonia, the AGM is a prime opportunity for shareholders to engage directly with the company's management...

Continue Reading