I believe he is playing of UB-421, when he said mo

I believe he is playing of UB-421, when he said mono is as close to a functional cure as possible. UB-421, which somehow got a time article with comment from Fauci, and published in New England Journal of Medicine because they mention this as being a functional cure and the potential of reducing the hiv reservoirs . But the paper itself made no mention of the reservoirs.

UB-421 has more side effects and isn't self-injectable as compared to leronlimab. So I'm not sure why they got all the publicity (and support from Fauci), while nothing for leronlimab.


http://time.com/5571818/hiv-injection-treatment/

Quote:

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Wang is hopeful that the results will be positive. Already, further analysis of the data from the current study suggest that longer remissions may be feasible. Not only did the antibody UB-421 block HIV from infecting new cells, but it also seemed to modify the study participants’ immune cells in ways that made them better able to fight off the virus. UB-421 seemed to activate certain immune cells to better recognize and destroy HIV, including the hard-to-reach reservoirs where the virus tends to hide from immune cells. “We think [UB-421] could be a great agent in future studies for activating T cells to do many things, including cleaning the body of virus,” she says.

If the immune system can be retrained to better ward off HIV, that could lead to longer and longer periods of pill-free treatment and even eventually, perhaps, to what experts call a functional cure for HIV — should UB-421 allow patients go years with undetectable HIV levels without needing pills or repeated antibody injections.

“We don’t know exactly what passively transferring antibodies is doing,” says Dr. Anthony Fauci, director of the National Institute on Allergy and Infectious Diseases, which partially supported the study. “But there is something going on to induce at least partially — not perfectly — better immune responses than the body naturally makes against the virus.”

Fauci notes that UB-421 works by mimicking the door on immune cells that HIV uses to enter and infect. Fauci and other researchers are also studying antibodies, called broadly neutralizing antibodies, that bind to HIV itself and prevent it from infecting cells. It’s likely that an effective, long-acting and pill-free treatment for HIV may involve a combination of agents like UB-421 and broadly neutralizing antibodies, says Fauci, so that HIV is both crippled and prevented from entering cells. “Something like that could be a knock-out punch,” he says.

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