With the TNBC/lerolimab trial, I believe ccr5 expression in

New Post Public Reply Private Reply Replies (1) Message Board
trding smlf #112
467
With the TNBC/lerolimab trial, I believe ccr5 expression in measured with a biopsy



Quote:
2) Demonstrate CCR5 + by IHC (>10% membranous staining completed at the reference laboratory of Dr. Hallgeir Rui at Medical College of Wisconsin).

Note: This test will be done as part of the pre-screening period. It will be performed in archival metastatic tissue. If archival tissue is not available then, fresh biopsy will be done;

3)Be willing to provide tissue from a newly obtained core or excisional biopsy of a tumor lesion (in case archival tissue is not available);





Here was a method they used to automate her 2 expression with ctcs.

Quantifying HER-2 expression on circulating tumor cells by ACCEPT.

Abstract
Quote:

Circulating tumor cells (CTCs) isolated from blood can be probed for the expression of treatment targets. Immunofluorescence is often used for both the enumeration of CTC and the determination of protein expression levels related to treatment targets. Accurate and reproducible assessment of such treatment target expression levels is essential for their use in the clinic. To enable this, an open source image analysis program named ACCEPT was developed in the EU-FP7 CTCTrap and CANCER-ID programs. Here its application is shown on a retrospective cohort of 132 metastatic breast cancer patients from which blood samples were processed by CellSearch® and stained for HER-2 expression as additional marker. Images were digitally stored and reviewers identified a total of 4084 CTCs. CTC's HER-2 expression was determined in the thumbnail images by ACCEPT. 150 of these images were selected and sent to six independent investigators to score the HER-2 expression with and without ACCEPT. Concordance rate of the operators' scoring results for HER-2 on CTCs was 30% and could be increased using the ACCEPT tool to 51%. Automated assessment of HER-2 expression by ACCEPT on 4084 CTCs of 132 patients showed 8 (6.1%) patients with all CTCs expressing HER-2, 14 (10.6%) patients with no CTC expressing HER-2 and 110 (83.3%) patients with CTCs showing a varying HER-2 expression level. In total 1576 CTCs were determined HER-2 positive. We conclude that the use of image analysis enables a more reproducible quantification of treatment targets on CTCs and leads the way to fully automated and reproducible approaches.


They presented a her2/ccr5 link with ctcs recently, but I have yet to find the poster to see how they determined the ccr5 expression with ctcs..

https://twitter.com/MCristofanill/status/1112363311415345155

https://twitter.com/LGerratana/status/1112250580334985217
Quote:
#CCR5 and #HER2 as #CTC based #circulating #biomarkers. New insights on #metastatic #BreastCancer #biology and promising new #therapeutic targets this afternoon at board 10, section 17 #CTC #MBC #PrecisionMedicine #AACR19


https://ativsoftware.com/appinfo.php?page=Int...mp;id=4723

http://www.siliconbiosystems.com/press-releas...ast-cancer



Scroll down for more posts ▼

Top 10 Most Recent News Articles

Propensity Rockets to No. 70 on the 2026 Inc. 5000 List

Updated Category News Views 6

Hold onto your hats, folks—Propensity just blasted its way to Number 70 on the Inc. 5000 for 2026. That's quite a leap from the 2,591 spot just last year. If you're scratching your head wondering what's behind this meteoric rise, it’s all about AI and knowing which buyer signals really matter. The AI Advantage in B2B The B2B marketing space isn't exactly the new Wild...

Continue Reading
Lyric Health's AI System Promises Data-Driven Revolution

Updated Category News Views 5

A Bold Step in Healthcare Coordination No doubt about it, healthcare is a mess. It's like trying to patch a leaking ship with duct tape—point solutions here, add-ons there, and nothing truly working in harmony. And in storms in Lyric Health, claiming they've got the answer. They've launched an AI-powered Healthcare Operating System meant to unify these disjointed pieces...

Continue Reading
Medicare Competitive Bidding May Slash Jobs, Access

Updated Category News Views 4

Medicare's New Program: Potential Knockout Punch? Today, we dive into Medicare's latest shake-up that might just be the unseen wrecking ball swinging toward thousands of jobs and small businesses in the healthcare sector. Two years from now, starting January 2028, the Competitive Bidding Program is set to reroute the entire landscape for suppliers of key medical products...

Continue Reading
Red Banyan Earns Top Honors in Florida for 2026

Updated Category News Views 6

Red Banyan: A Powerhouse in Reputation Management Boy, have you ever watched a company rise through the ranks almost like a caffeine kick on a drowsy morning? That's Red Banyan for you. This outfit, right out of Fort Lauderdale, snagged the '2026 Best of Florida' award as the cream of the crop in the Business Consulting Firms category. It’s like taking home an Oscar in...

Continue Reading
Finastra Recognized as 2026 Leader in Payment Platforms

Updated Category News Views 5

Finastra Steals the Spotlight in Payments Innovation When it comes to the modern world of finance, nothing screams ‘adapt or fade into oblivion’ like the payments industry. Well, here’s a reality check from QKS Group: Finastra has snatched the spotlight in their SPARK Matrix™ for 2026 as a powerhouse in integrated bank payments platforms. Clearly, this ain’t...

Continue Reading
Ransoms and Mega-Losses Surge in Cyber Claims Study

Updated Category News Views 5

Cyber Costs Skyrocket in Latest Study NetDiligence’s 2026 Cyber Claims Study isn't just another report—it’s a wake-up call. The numbers paint a stark picture: cyber incidents are burning deeper holes in pockets, and no one's immune. Whether you're a scrappy SME or a lumbering corporate giant, this report puts a magnifying glass to the chilling reality of cyber...

Continue Reading
OrthoAtlanta Expands with Dr. Smith's Expertise Hire

Updated Category News Views 4

OrthoAtlanta Welcomes New Orthopedic Surgeon In a world where healthcare organizations are constantly stretching their wings, this new addition of Dr. Carson J. Smith to the fold at Piedmont Orthopedics | OrthoAtlanta stands out. This isn't just some cosmetic face-lift, folks. It's a real investment in the community, not to mention a crucial broadening of what this...

Continue Reading
2026 CEE Awards Highlight Energy Innovation Leaders

Updated Category News Views 7

Showcasing Cutting-Edge Home Energy Innovations It's that time of year again when the brightest innovators in home energy solutions get a nod from the Consortium for Energy Efficiency (CEE). This year's Integrated Home Competition spotlighted five trailblazing products that promise to reshape how we think about energy efficiency, demand flexibility, and sheer user comfort...

Continue Reading
American Savings Bank IPO Hits NYSE: $129M Raised

Updated Category News Views 8

A Big Day for American Savings Bank Buckled up yet? Because American Savings Bank has just shot onto the NYSE, raising a hefty $129 million. A solid start, I’d say, for a Honolulu-based outfit that now struts around with a valuation tipping beyond $1.03 billion. That’s what you get when you price more than eight million shares at $16 a pop. NYSE:ASBH is the new kid on...

Continue Reading
Koogler's Sale to ALL4: A Game-Changer for the Southeast

Updated Category News Views 6

A Strategic Alignment Unfolds in Environmental Engineering Ever notice how those industry shifts often sneak up on you, only to leave a mark that's hard to ignore? That's exactly what's playing out with Koogler & Associates' recent hookup with ALL4 LLC. Set aside that coffee, this one's too important to miss if you've got a stake in the environmental consulting game or...

Continue Reading

Top 5 Most Recently Viewed Articles

Strategic Boost for Inseego as George Mulhern Joins Board

Updated Category News Views 140

Inseego Welcomes George Mulhern to Its Board of Directors Inseego Corp. (Nasdaq: INSG) is thrilled to announce the appointment of George Mulhern, a distinguished leader in the wireless technology sector, to its Board of Directors. With a profound background in developing and steering wireless tech companies, Mr. Mulhern has most recently held the position of Senior Vice...

Continue Reading
Economic Outlook Raises Concerns of Inflation Under Trump

Updated Category News Views 128

Increased Economic Concerns with Trump's Return Recent findings reveal that economists are increasingly worried about the potential return of former President Donald Trump and its effects on inflation and federal deficits. Survey Findings on Inflation and Economic Policies A survey conducted by a group of economists indicates a majority foresee higher inflation and...

Continue Reading
Join the Class Action Against Rocket Pharmaceuticals Today

Updated Category News Views 134

Join the Class Action Against Rocket Pharmaceuticals Investors are being called to participate in a class action lawsuit concerning Rocket Pharmaceuticals, Inc. (NASDAQ: RCKT). This lawsuit is aimed at recovering losses incurred by shareholders due to alleged securities fraud that impacted the company's financial standing during a specified timeframe. Understanding the...

Continue Reading
Nipocalimab Receives Priority Review from U.S. FDA for gMG

Updated Category News Views 297

Nipocalimab Secures U.S. FDA Priority Review Status Johnson & Johnson (NYSE: JNJ) has exciting news regarding its investigational drug, Nipocalimab. The U.S. Food and Drug Administration (FDA) has granted Priority Review designation for Nisocalimab as a treatment for generalized myasthenia gravis (gMG) in patients with specific autoantibodies. This important milestone...

Continue Reading
Navigating the Canadian Multifamily Landscape: Supply and Demand

Updated Category News Views 89

Understanding Canada's Multifamily Market Trends In recent times, the Canadian multifamily housing market has exhibited some intriguing trends, particularly concerning rent growth and vacancy rates. As highlighted in the latest report from Yardi Canada, the market showcases a scenario where rent growth is slowing, while vacancies remain low. This situation reflects the...

Continue Reading