CD4+ memory T-cells (where hidden HIV reservoirs h
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Posted On: 05/17/2019 5:47:59 PM
Re: Nt2innvovate #3075
CD4+ memory T-cells (where hidden HIV reservoirs hide) differentiate themselves after the naive CD4+ T-cells are already produced and in response to an event. As long as there are any CD4+ cells with active CCR5 receptors than CCR5 specific HIV can reproduce when the hidden reservoirs of HIV activate.
With CD32 T-cells there are no CCR5 receptors. With bone marrow transplants chemo will destroy the existing blood producing cells so any replacement with CD32 variant will only produce non-CCR5 expressive T-cells. There will be no place for HIV to latch on and replicate.
Since the reservoirs exist outside of the marrow a non-CD32 transplant will not stop HIV.
Best case scenario - The half life of CD4+ memory T-cells is 44 months. Without a virological event leronlimab may be able to block all CCR5 receptors, keeping new CD4+ memory T-cells from becoming infected. So every 44 months, under best conditions, half the reservoir ceases to exist. Over a very long period of time leronlimab may effectuate a cure.
With CD32 T-cells there are no CCR5 receptors. With bone marrow transplants chemo will destroy the existing blood producing cells so any replacement with CD32 variant will only produce non-CCR5 expressive T-cells. There will be no place for HIV to latch on and replicate.
Since the reservoirs exist outside of the marrow a non-CD32 transplant will not stop HIV.
Best case scenario - The half life of CD4+ memory T-cells is 44 months. Without a virological event leronlimab may be able to block all CCR5 receptors, keeping new CD4+ memory T-cells from becoming infected. So every 44 months, under best conditions, half the reservoir ceases to exist. Over a very long period of time leronlimab may effectuate a cure.
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