For those who prefer verbal presentations, here is
Post# of 72440
Quote:
Trial Results—Clear Efficacy Signal in the More Aggressive Chemotherapy Regimen
Brilacidin-OM was more effective in decreasing the incidence of SOM in Head and Neck Cancer (HNC) patients receiving the more aggressive chemotherapy regimen — cisplatin administered in a higher concentration (80-100 mg/m2), every 21 days — as compared to lower concentrations of cisplatin (30-40 mg/m2) administered weekly.
For the modified Intent-to-Treat (mITT) population, Brilacidin-OM in the aggressive chemotherapy regimen reduced the relative incidence of SOM by 65.0% ([incidence control - incidence active] / incidence control) where the group incidence rates were Brilacidin: 25.0%; placebo: 71.4% (p=0.048). For the Per Protocol (PP) population, Brilacidin-OM in the aggressive chemotherapy regimen similarly reduced the relative incidence of SOM by 80.3% (Brilacidin: 14.3%; placebo: 72.7%) (p=0.025). The q3wk dosing regimen aligns with current standard-of-care for cisplatin chemotherapy. Brilacidin-OM also delayed the onset of SOM and reduced the duration of SOM. Treatments appeared well-tolerated with good safety.
http://www.ipharminc.com/new-blog/2018/9/24/b...l-om-drugs