CTCs during phase 1b of TNBC trail Phase 1b loo
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Posted On: 03/06/2019 4:07:03 AM
CTCs during phase 1b of TNBC trail
Phase 1b looks to be initially the trial‘s first 21 day treatment cycle. The CTC level is recorded day 1 of each treatment cycle to compare against baseline.
This phase 1b should also allow them to compare CTC changes at the different doses 350 vs 525 vs 700mg, which will be very interesting data to analyze: ctc/dose day 1 vs day 22
Phase 1b looks to be initially the trial‘s first 21 day treatment cycle. The CTC level is recorded day 1 of each treatment cycle to compare against baseline.
This phase 1b should also allow them to compare CTC changes at the different doses 350 vs 525 vs 700mg, which will be very interesting data to analyze: ctc/dose day 1 vs day 22
Quote:
Phase Ib: Maximum Tolerated Dose (MTD) of leronlimab (PRO 140) when combined with carboplatin AUC5 [ Time Frame: Cycle 1 (21 days) ]
Quote:
Phase II: The change from baseline in circulating tumor cells (CTC) level in the peripheral blood. [ Time Frame: Every 21 days (i.e., Day 1 of each treatment cycle) through treatment completion, an average of 6 months. ]
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