A couple comments reading wiki hints the GvHD he had might have been the cure, because until now this failed when they tried again but seems to have work with others with gvhd.. I will have to look more. Also why leronlimab is not a 'cure' because if they it blocks entry, the HIV virus still has a reservoir, hiding out in effector memory T-cells which can clone themselves.
It is an interesting coincidence that brown had hiv, gvhd, and cancer all gone now.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248834/.
“This virus inserts its genome into the body's memory cells and sits there quietly avoiding detection by the immune system,” she said.
wiki:
[img]Brown, the "Berlin patient", suffered from graft-versus-host disease and leukoencephalopathy – both transplant complications that are potentially fatal. This means that the procedure should not be performed on others with HIV, even if sufficient numbers of suitable donors could be found. In fact, there is now some doubt that Timothy Brown's apparent cure was due to the unusual nature of the stem cells he received. The graft-versus-host disease Brown suffered from could have been what eliminated the HIV virus from his system.
As of 2017, six more people also appear to have been cleared of HIV after getting graft-versus-host disease; only one of them had received CCR5 mutant stem cells, so it appears that when a transplant recipient has graft-versus-host disease the transplanted cells may kill off the host's HIV-infected immune cells[/img]
It is an interesting coincidence that brown had hiv, gvhd, and cancer all gone now.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248834/.
“This virus inserts its genome into the body's memory cells and sits there quietly avoiding detection by the immune system,” she said.
wiki:
[img]Brown, the "Berlin patient", suffered from graft-versus-host disease and leukoencephalopathy – both transplant complications that are potentially fatal. This means that the procedure should not be performed on others with HIV, even if sufficient numbers of suitable donors could be found. In fact, there is now some doubt that Timothy Brown's apparent cure was due to the unusual nature of the stem cells he received. The graft-versus-host disease Brown suffered from could have been what eliminated the HIV virus from his system.
As of 2017, six more people also appear to have been cleared of HIV after getting graft-versus-host disease; only one of them had received CCR5 mutant stem cells, so it appears that when a transplant recipient has graft-versus-host disease the transplanted cells may kill off the host's HIV-infected immune cells[/img]
