Aluminium https://www.alzheimers.org.uk/about-

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Aluminium

https://www.alzheimers.org.uk/about-dementia/...d-dementia

In 1965, researchers found that rabbits injected with an extremely high dose of aluminium developed toxic tau tangles in their brains. This led to speculation that aluminium from cans, cookware, processed foods and even the water supply could be causing dementia. The ability of this high dose aluminium to induce tau tangles, increase amyloid levels and contribute to the development of plaques has been shown in laboratory experiments on animals.

Importantly, these results were only seen with extremely high exposures that far exceed the levels that can enter the body through food or potentially through contact with aluminium cookware.

Since this study was reported, much research has been done on the relationship of aluminium and Alzheimer's disease. As yet no study or group of studies has been able to confirm that aluminium is involved in the development of Alzheimer's disease.

Aluminium is seen in the normal, healthy brain. It is not clear how aluminium is getting into the brain from the blood. The levels currently seen in peoples brains hasn't been shown to be toxic but an ageing brain may be less able to process the aluminium.

Although aluminium has been seen in amyloid plaques there is no solid evidence that aluminium is increased in the brains of people with Alzheimer's disease. No convincing relationship between amount of exposure or aluminium in the body and the development of Alzheimer's disease has been established.

Aluminium in food and drink is in a form that is not easily absorbed in to the body. Hence the amount taken up is less than 1% of the amount present in food and drink. Most of the aluminium taken into the body is cleaned out by the kidneys.

Studies on people with kidney problems have shown increased amounts of aluminium in the brain, due to the inability of the kidneys to pass it into the urine. Although toxic effects were seen on the brain in these people, none of these were related to Alzheimer's disease.

One large recent study did find a potential role for high dose aluminium in drinking water in progressing Alzheimer's disease for people who already have the disease.

However, multiple other small and large scale studies have failed to find a convincing causal association between aluminium exposure in humans and Alzheimer's disease.

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