A couple of posts from ihub,
Fletch
falconer66a Monday, 08/20/18 12:55:23 PM
Re: lqmike post# 163245 0
Post #
163251
of 163257
Life-long Anavex Dosing?
If Anavex 2-73 (or any of the other Anavex molecules) proves to be profoundly prophylactic (disease-preventing) — as I think will be the case — the best age to begin dosing will need to be determined. Age 50? Seems reasonable to prevent Alzheimer’s. Not many show symptoms before that age. But, yes, other central nervous system diseases can have earlier onsets.
Several questions will have to be answered. Big one is this. Just what diseases and conditions might Anavex sigma-1 receptor agonists prevent when administered early enough?
What if it turns out that a host of human diseases result from, or are allowed to happen because intrinsic, natural sigma-1 receptor agonists fail at various stages of development or aging?
Now, this is a universal, uncontested biological fact. Virtually all chemical reactions in organisms are controlled, mediated, and promoted by precisely-formed, folded enzyme proteins. Mis-fold or distort an enzyme, and biochemical processes are disrupted. Many neurotoxin poisons of snakes and other organisms work by distorting enzyme shapes. They can no longer control or promote normal chemical reactions; death or injury ensue. A number of genetic diseases are known to occur when essential enzymes are improperly, incompletely, or absently produced. Most often, that happens because of a genetic defect; the nucleotide sequence of the controlling gene is out of order.
So, what if it’s discovered that Anavex sigma-1 receptor agonists restore normalized enzyme production in a host of cell types, at a variety of developmental stages, even embryonic? Too lengthy for me to deliberate the matter here, but for me, examination of all of the known murine study data, and the hints on the matter revealed by the Anavex pipeline drugs and the diseases they may treat, I am lead to believe that the roles Anavex sigma-1 receptor agonists might play in preventing just a host of developmental diseases and conditions, even in the uterus, could be (to use a phrase) “an iceberg.”
falconer66a Monday, 08/20/18 12:11:31 PM
Re: plexrec post# 163238 0
Post #
163243
of 163257
The Inflammation Factor
Yes, the “waste proteins” of Alzheimer’s, the beta-amyloids and tau tangles, are decidedly inflammatory, as proven in murine studies. Inflammation of nerves and nerve tissues is always problematic. When inflammation is well-controlled and properly restrained, it initiates and modulates appropriate immunological attacks on extrinsic pathogens, bacteria in particular; in some cases viruses. Well and good.
But inflammation can call out too many immunological defense troops (empowered leucocytes) who then fail to discriminate between invading, infecting pathogens from normal body cells and tissues. Not only are pathogens “controlled,” normal cells and tissues are attacked and slain. One needn’t know much biology to imagine what results when nerves are so attacked.
The author states, “It seems that if given early enough ANAVEX 2-73 can stop or even reverse progress of the disease.”
If Anavex 2-73 can cause neurons to accurately create proteins, by allowing endoplasmic reticula to function normally, enzyme proteins will be folded into their proper, functioning shapes, thereby creating normalized, healthful chemistries within the neuron. No disease onset.
Personally, I’ve contended this myself a number of times. Administering Anavex 2-73 after beta amyloid and tau wastes have profusely accumulated and induced neuron-destroying inflammation may not be useful. The wastes have accumulated, induced inflammation, and affected neurons cannot be salvaged. But start the treatment early, before waste proteins have much accumulated, and the normalized protein enzymes from the Anavex-restored endoplasmic reticula will maintain, even restore neuron function.
Why wait to treat Alzheimer’s with Anavex 2-73 until severe, irreversible damage to neurons and nerves has occurred? Treat at the very first signs of Alzheimer’s, before irrevocable damage has occurred, before waste proteins have accumulated to any degree.
With 300 people taking Anavex 2-73 in the upcoming trial, a computer’s plotting of outcomes should reveal if this scenario is accurate. If it is, those taking the drug at earlier stages of the disease will have better results. Those at more advanced stages will have reduced positive outcomes.
I’ve also contended that eventually Anavex 2-73 may be universally prescribed to virtually every one, at some yet to be determined age, say, age 50. With that, any of the central nervous system diseases (or others) can be prevented from developing. Treated and prevented at the start, before any irrevocable, chronic damage has been done.
When you were ten, your mother in winter used to say, “Better put on your coat. We don’t want you to catch a cold.” Will physicians sometime be saying to their mid-aged patients, “Well, I see you are approaching your 50th birthday. Time for you to start taking an Anavex pill each day. We don’t want you to develop any of those horrible diseases people used to get?”
https://investorshub.advfn.com/Anavex-Life-Sc...VXL-11474/
Fletch
falconer66a Monday, 08/20/18 12:55:23 PM
Re: lqmike post# 163245 0
Post #
163251
of 163257
Life-long Anavex Dosing?
If Anavex 2-73 (or any of the other Anavex molecules) proves to be profoundly prophylactic (disease-preventing) — as I think will be the case — the best age to begin dosing will need to be determined. Age 50? Seems reasonable to prevent Alzheimer’s. Not many show symptoms before that age. But, yes, other central nervous system diseases can have earlier onsets.
Several questions will have to be answered. Big one is this. Just what diseases and conditions might Anavex sigma-1 receptor agonists prevent when administered early enough?
What if it turns out that a host of human diseases result from, or are allowed to happen because intrinsic, natural sigma-1 receptor agonists fail at various stages of development or aging?
Now, this is a universal, uncontested biological fact. Virtually all chemical reactions in organisms are controlled, mediated, and promoted by precisely-formed, folded enzyme proteins. Mis-fold or distort an enzyme, and biochemical processes are disrupted. Many neurotoxin poisons of snakes and other organisms work by distorting enzyme shapes. They can no longer control or promote normal chemical reactions; death or injury ensue. A number of genetic diseases are known to occur when essential enzymes are improperly, incompletely, or absently produced. Most often, that happens because of a genetic defect; the nucleotide sequence of the controlling gene is out of order.
So, what if it’s discovered that Anavex sigma-1 receptor agonists restore normalized enzyme production in a host of cell types, at a variety of developmental stages, even embryonic? Too lengthy for me to deliberate the matter here, but for me, examination of all of the known murine study data, and the hints on the matter revealed by the Anavex pipeline drugs and the diseases they may treat, I am lead to believe that the roles Anavex sigma-1 receptor agonists might play in preventing just a host of developmental diseases and conditions, even in the uterus, could be (to use a phrase) “an iceberg.”
falconer66a Monday, 08/20/18 12:11:31 PM
Re: plexrec post# 163238 0
Post #
163243
of 163257
The Inflammation Factor
Yes, the “waste proteins” of Alzheimer’s, the beta-amyloids and tau tangles, are decidedly inflammatory, as proven in murine studies. Inflammation of nerves and nerve tissues is always problematic. When inflammation is well-controlled and properly restrained, it initiates and modulates appropriate immunological attacks on extrinsic pathogens, bacteria in particular; in some cases viruses. Well and good.
But inflammation can call out too many immunological defense troops (empowered leucocytes) who then fail to discriminate between invading, infecting pathogens from normal body cells and tissues. Not only are pathogens “controlled,” normal cells and tissues are attacked and slain. One needn’t know much biology to imagine what results when nerves are so attacked.
The author states, “It seems that if given early enough ANAVEX 2-73 can stop or even reverse progress of the disease.”
If Anavex 2-73 can cause neurons to accurately create proteins, by allowing endoplasmic reticula to function normally, enzyme proteins will be folded into their proper, functioning shapes, thereby creating normalized, healthful chemistries within the neuron. No disease onset.
Personally, I’ve contended this myself a number of times. Administering Anavex 2-73 after beta amyloid and tau wastes have profusely accumulated and induced neuron-destroying inflammation may not be useful. The wastes have accumulated, induced inflammation, and affected neurons cannot be salvaged. But start the treatment early, before waste proteins have much accumulated, and the normalized protein enzymes from the Anavex-restored endoplasmic reticula will maintain, even restore neuron function.
Why wait to treat Alzheimer’s with Anavex 2-73 until severe, irreversible damage to neurons and nerves has occurred? Treat at the very first signs of Alzheimer’s, before irrevocable damage has occurred, before waste proteins have accumulated to any degree.
With 300 people taking Anavex 2-73 in the upcoming trial, a computer’s plotting of outcomes should reveal if this scenario is accurate. If it is, those taking the drug at earlier stages of the disease will have better results. Those at more advanced stages will have reduced positive outcomes.
I’ve also contended that eventually Anavex 2-73 may be universally prescribed to virtually every one, at some yet to be determined age, say, age 50. With that, any of the central nervous system diseases (or others) can be prevented from developing. Treated and prevented at the start, before any irrevocable, chronic damage has been done.
When you were ten, your mother in winter used to say, “Better put on your coat. We don’t want you to catch a cold.” Will physicians sometime be saying to their mid-aged patients, “Well, I see you are approaching your 50th birthday. Time for you to start taking an Anavex pill each day. We don’t want you to develop any of those horrible diseases people used to get?”
https://investorshub.advfn.com/Anavex-Life-Sc...VXL-11474/
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