Technology may be a little different but the patent applied for Oct 29, 2015 is similar and if granted should be announced within the next couple months.
Specifics of The Patent Application:
The perivascular cell mixture (the "Cell Mixture"
is created using the Company's Cytotronics™ platform and the co-culture of immunologically privileged and modulatory stem cells from a portion of the human umbilical cord along with adipose stem cells and a mixture of cord blood cells to create an off-the-shelf therapeutic product that can be stored indefinitely in a low temperature freezer and used to treat blood-related disorders.
Researchers had previously identified endothelial and perivascular cells, which line blood vessels, as the cells that functionally support blood-forming stem cells in the body. Endonovo's use of a perivascular co-culture in a three-dimensional bioreactor allows for the maintenance and expansion of blood-forming stem cells in an environment that more closely resembles the way that they renew inside of the body.
Endonovo Therapeutics had previously announced a large-scale method of expanding cord blood using a co-culture with perivascular cells in a three-dimensional bioreactor. The Company had also previously announced the launch of its Cytotronics™ Platform, which uses its Time-Varying Electromagnetic Field (TVEMF) technology to expand and create optimized stem cells that show increased proliferation and the increased expression of several key genes that influence their "stemness," homing and engraftment potential.
Endonovo Therapeutics has combined the two technologies to create a large-scale method of expanding and optimizing the biological properties of blood-forming stem cells prior to their transplantation and for the production of an off-the-shelf therapeutic product that can be stored indefinitely in a low temperature freezer without requiring cryopreservation.
"Current methods of expanding blood-forming stem cells outside of the body mainly expand short-term progenitors at the expense of the long-term self-renewing stem cells. Therefore, clinicians need to administer a second un-manipulated cord blood unit in addition to the expanded unit in adult patients in order to provide long-term hematopoiesis," commented Endonovo Chief Scientist, Dr. Donnie Rudd. "Our off-the-shelf therapeutic is created using perivascular cells and a bioreactor that supports and mimics the way that blood-forming stem cells reside and renew inside of the body."
"By combining the two technologies, we are addressing the problem from two sides," stated Endonovo CEO, Alan Collier. "We are expanding the number of blood-forming stem cells and also enhancing the biological properties of these stem cells to create enhanced cell therapies."
"Our competitors are primarily using genetic modification and/or pharmacological modulation to expand and/or enhance the therapeutic properties of stem cells, while we are simply using physical energy and a simulated stem cell environment, which we believe will result in safer and more effective therapies," concluded Mr. Collier.
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