Discussion between 1oldprof, SLC, Peteman and frroll:
Quote:1oldprof Saturday, 06/24/17 02:18:32 PM
Re: cabel post# 187185
Post # of 187257
If I am looking at the correct chemical structure of Brilacidin, I disagree with your assertion. A peptide bond is formed by the joining of a carboxyl group and an amino group. I see 4 of these in Brilacidin. The key for B is that they are not in series, thus it is not a polypeptide per se but it does have peptide bonds thus...peptidic.
Quote:slcimmuno Member Level Saturday, 06/24/17 02:22:54 PM
Re: 1oldprof post# 187239
Post # of 187257
Good to see you posting
I'm no PhD but my read of the "Nonpeptidic" claim to Brilacidin and the other HDP-Ms is that they are polymers (synthetic) and thus not real peptides ... mimetic of that are more stable, selective and potent -- designed to be better than what even Ma Nature made -- like the $6million dollar man. My 02c.
Quote:1oldprof Saturday, 06/24/17 02:32:46 PM
Re: slcimmuno post# 187240
Post # of 187257
Non polypeptide would be more accurate. It has peptide bonds in it. Dr Zasloff may have been referring to these. It is NOT a protein and that is what is key IMO. I am not an organic or biochemist by trade but I used to know my way around this stuff....but I am happy to admit my error if it is so. But before sending messages to mgt, I just thought you would want to know this
Quote:1oldprof Saturday, 06/24/17 02:36:47 PM
Re: slcimmuno post# 187240
Post # of 187257
And "polymer" does not refer to synthetic compounds strictly in the resesrch world. There are synthetic polymers, but many many polymeric compounds that are found in nature
Quote:slcimmuno Member Level Saturday, 06/24/17 02:38:37 PM
Re: 1oldprof post# 187241
Post # of 187258
Googled one of the old Polymedix decks -- this might give you some more context / insight into the "non-peptidic" usage, history of the HDP-Ms pre IPIX
Feel free to share any thoughts
http://files.shareholder.com/downloads/ABEA-4...l_Peptides
Quote:slcimmuno Member Level Saturday, 06/24/17 02:38:37 PM
Re: 1oldprof post# 187241
Post # of 187258
Googled one of the old Polymedix decks -- this might give you some more context / insight into the "non-peptidic" usage, history of the HDP-Ms pre IPIX
Feel free to share any thoughts
http://files.shareholder.com/downloads/ABEA-4...l_Peptides
Quote:1oldprof Saturday, 06/24/17 03:05:05 PM
Re: slcimmuno post# 187243
Post # of 187258
Thanks for that! I had done some reading previous to investing. Honestly, I think they meant "non-protein" as non-peptidic. I wouldn't know what Zasloff was referring to with peptidic, just conjecturing. From my perspective, "non proteinaceous" would have been much less ambiguous.
Quote:frrol Member Level Saturday, 06/24/17 03:14:05 PM
Re: 1oldprof post# 187241
Post # of 187258
Thanks all for this discussion. It appears there is some grey area in the scientific terminology, which can explain the 'opposing' assertions. I think we got some clarity today.
Quote:frrol Member Level Saturday, 06/24/17 03:17:00 PM
Re: slcimmuno post# 187240
Post # of 187258
Perhaps it also improves the oral bioavailability of B through the digestive tract. Not sure.
Quote:1oldprof Saturday, 06/24/17 03:24:49 PM
Re: petemantx post# 187245
Post # of 187258
Hey Pete, I was working on a floor above on something else. In retrospect, what I was working on was central to inflammatory processes and has been invaluable. But researchers talk at the water cooler too and went to a bunch of talks on p53 and what was cutting edge AT THE TIME. I used to consider p53 a pipe dream. But not so much anymore. Honestly, the poster by "independent researchers" had some really fascinating findings on the Western blots, some not what I would have expected and points to a, surprise surprise, much more complex system than a simple linear relationship. The planned genetic expression work which the researchers alluded to is, hopefully, going to crystallize this more. Yes, I think that p53 and some of the recent successes in clarification will spawn a whole new approach to cancer IMO. From a research standpoint, and a BP standpoint, mAbs were much easier to approach and faster to get a product on the market. Was it the best approach? Too lengthy to message. I think you will see a multi pronged approach to cancer and the research will bear that out. p53 is here to stay.
Btw, "independent researchers" has got to refer to Bologna and I, for one, am stoked to see that this has not fizzled away. Would love to see MD Anderson too, maybe in time
Quote:georgejjl Saturday, 06/24/17 03:27:44 PM
Re: 1oldprof post# 187163
Post # of 187258
Imagine Prurisol as an oral drug for treating psoriasis, psoriatic athritis, rheumatoid arthritis, etc. and Brilacidin as a topical treatment for the same conditions.
Good luck and GOD bless,
George
Quote:1oldprof Saturday, 06/24/17 03:29:56 PM
Re: petemantx post# 187245
Post # of 187258
To answer a little further, I think Kevetrin and the other compound being developed by that private firm, name escapes me, has been a shot across the bow and has led to a lot more visibility
Quote:1oldprof Saturday, 06/24/17 03:33:29 PM
Re: georgejjl post# 187252
Post # of 187258
If they could get B in an oral formulation and if they show modulation of IL17, the two together would be HUGE! If B orally turns into an issue, there are many routes to try. Topical would be interesting!
Quote:slcimmuno Member Level Saturday, 06/24/17 04:44:30 PM
Re: frrol post# 187249
Post # of 187258
Have been some good Convos today on the Science if you can manage to avoid the lightweight Bunk.
Bodacious Brilacidin is Bankable imo.
Already compared favorably as a single-dose to 7-day Dapto, a Bn+ in ABSSSI, and now its coming thru strong as a topical in OM and IBD. That there is negligible systemic absorption but high efficacy suggests its profile as a topical should remain rather benign... as it works its Host Defense wonders.
Re formulation and delivery, IPIX seems quite confident they can turn it into foam/gel and pill. That would be huge for GI -- UC and Crohns. The biologics, with their bad side effects, are mediocre here so lots of room for B to enter. Think B as a drug that is as good as or better than them ... similar to Prurisol for PsO.
DeGrado and his group deserve a lot of credit for designing B but IPIX does too: finding a tarnished but real (not fake) diamond in the rough and polishing it up, particularly as to its anti-inflammatory properties.
Brilacidin's moment to shine fast approaching... IBD OM DERM on top of ABX. And there are more areas beyond that.
Big Pharma always says they want a Platform drug, well B is showing signs of becoming exactly that...
If the oppty presents, I say sell Prurisol and put the $$$ back into B ... rightly formulated it has Multiple Blockbusters written already over it. Kevetrin could follow a similar path -- formulate it as an Oral to leverage its PK, then test it across multiple areas.
Exciting times ahead.
2
