Article - Stabilised mutant p53 is an important de
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Posted On: 06/13/2017 8:15:34 PM
Article - Stabilised mutant p53 is an important determinant of tumour survival and a valid drug target
"A mutant p53 protein must be stabilised in order to function, and, in fact, constituent stabilisation of aberrant p53 protein is a characteristic feature of tumours with gain-of-function TP53 mutations."
"These findings suggest that destabilisation of p53 carrying gain-of-function mutations might be a useful strategy against tumours with this type of mutation."
http://ecancer.org/news/7337-stabilised-mutan...target.php
In a related story, Kevetrin degrades mutant p53.
"A mutant p53 protein must be stabilised in order to function, and, in fact, constituent stabilisation of aberrant p53 protein is a characteristic feature of tumours with gain-of-function TP53 mutations."
"These findings suggest that destabilisation of p53 carrying gain-of-function mutations might be a useful strategy against tumours with this type of mutation."
http://ecancer.org/news/7337-stabilised-mutan...target.php
In a related story, Kevetrin degrades mutant p53.
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