**COULD THIS BE THE NEW DELIVERY SYSTEM?** http
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Posted On: 04/21/2017 12:33:25 PM
**COULD THIS BE THE NEW DELIVERY SYSTEM?**
Is an Asthma Inhaler OWCP's next delivery system and target?
Why the Inhaler delivery system?
Fastest method of delivery cannabinoids into the blood stream while being able to accurately dose each inhale.
Can Cannabinoids treat Asthma attacks?
There are 24 million Americans who are living with asthma today. THC can function as a temporary bronchodilator. Anti-inflammatory, regulates muscle spasms (which is how it treats IBS), antispasmodic properties.
Why an Inhaler vs. Smoking?
..So someone who can't breath properly is going to be treated by a drug that is most popularly smoked.. How dumb does that sound? Most would think that's an unimaginable scenario and just an outright dumb decision. (Most would be mistaken). It's hard to imagine an asthma sufferer reaching for a joint or bong when they need immediate relief. Some would think they would end up being more choked up by the smoke and lack of fresh air. However, some pre-clinical studies are proving that cannabinoids, when introduced to lung tissue directly can have a significant effect on reducing the inflammation and regulating immune responses that can cause asthma attacks.
How is asthma similar to psoriasis and IBS?
The inflammatory mechanic similarities between psoriasis, fibromyalgia, asthma and IBS are very similar. They can happen due to unregulated immune response cascades. With asthma most people are atopic (allergic to external triggers in the airways). Anxiety, stress, laughter. Airways narrow and cause wheezing. Mucous is produced in the lining and clogs the airways (mild, moderate, and severe). Narrowing of airways is reversible if trigger is removed or treated medically. Preventative treatment for an acute asthma attack: Mast cells contains granules rich in histamine and heparin. Role in allergy, play protective role in wound healing and defense against pathogens.In anaphylaxis (severe systemic reaction to allergens, such as nuts, bee stings or drugs), body-wide degranulation of mast cells leads to vasodilation and, if severe, symptoms of life-threatening shock. Histamine is a vasodilatory substance released during anaphylaxis.
What happens during an asthma attack?
Asthma is an immune response going overboard. A part of our body's natural response to a foreign body that then causes us harm by reacting to strongly and releasing things that cause us discomfort. IgE works with immune system to find mast cells. The mast cells contain granules rich in histamine. The IgE carries a foreign substance to the mast cell to attach to. The attachment wakes up the mast cells and the granule pockets open and release the histamine into the blood stream. Smooth muscle layer controls the diameter of the lumen (opening). Smooth muscle you can't control consciously. It reacts to the environment. Mucosa layer coats the inside opening of the airway. Glands in the mucosa keep our airways moist so they can clear out the debris with phlegm. During asthma, the muscles spasm (constricting) and the airway opening is getting much smaller. The smooth muscular layer has thickened and is clamping down on the opening. The mucosa layer has been compressed inward and decreases the lumen further. The glands continue to secrete mucous into the lumen which makes matters worse. Coughing and wheezing follow.
Conclusion:
Since OWC is already doing research on cannabinoids and their synergistic effects with the human immune system. Mainly focused on the functions dealing with white blood cells, cytokines and interleukins. Their studies could easily adapted for asthma since they will already have a wealth of information on how THC/CBD interact with certain immune functions. Just one more huge, exciting possibility for the company!
Sources:
https://www.youtube.com/watch?v=ZKvatbn4a_I (Asthma pathophysiology | Respiratory system)
https://www.youtube.com/watch?v=MoM5JY_EeRo Mast Cell (How Allergy Works)
https://www.youtube.com/watch?v=DZw--EZLEus (Asthma Cannabis Treatment Works Wonders On Lungs and Breathing)
Is an Asthma Inhaler OWCP's next delivery system and target?
Why the Inhaler delivery system?
Fastest method of delivery cannabinoids into the blood stream while being able to accurately dose each inhale.
Can Cannabinoids treat Asthma attacks?
There are 24 million Americans who are living with asthma today. THC can function as a temporary bronchodilator. Anti-inflammatory, regulates muscle spasms (which is how it treats IBS), antispasmodic properties.
Why an Inhaler vs. Smoking?
..So someone who can't breath properly is going to be treated by a drug that is most popularly smoked.. How dumb does that sound? Most would think that's an unimaginable scenario and just an outright dumb decision. (Most would be mistaken). It's hard to imagine an asthma sufferer reaching for a joint or bong when they need immediate relief. Some would think they would end up being more choked up by the smoke and lack of fresh air. However, some pre-clinical studies are proving that cannabinoids, when introduced to lung tissue directly can have a significant effect on reducing the inflammation and regulating immune responses that can cause asthma attacks.
How is asthma similar to psoriasis and IBS?
The inflammatory mechanic similarities between psoriasis, fibromyalgia, asthma and IBS are very similar. They can happen due to unregulated immune response cascades. With asthma most people are atopic (allergic to external triggers in the airways). Anxiety, stress, laughter. Airways narrow and cause wheezing. Mucous is produced in the lining and clogs the airways (mild, moderate, and severe). Narrowing of airways is reversible if trigger is removed or treated medically. Preventative treatment for an acute asthma attack: Mast cells contains granules rich in histamine and heparin. Role in allergy, play protective role in wound healing and defense against pathogens.In anaphylaxis (severe systemic reaction to allergens, such as nuts, bee stings or drugs), body-wide degranulation of mast cells leads to vasodilation and, if severe, symptoms of life-threatening shock. Histamine is a vasodilatory substance released during anaphylaxis.
What happens during an asthma attack?
Asthma is an immune response going overboard. A part of our body's natural response to a foreign body that then causes us harm by reacting to strongly and releasing things that cause us discomfort. IgE works with immune system to find mast cells. The mast cells contain granules rich in histamine. The IgE carries a foreign substance to the mast cell to attach to. The attachment wakes up the mast cells and the granule pockets open and release the histamine into the blood stream. Smooth muscle layer controls the diameter of the lumen (opening). Smooth muscle you can't control consciously. It reacts to the environment. Mucosa layer coats the inside opening of the airway. Glands in the mucosa keep our airways moist so they can clear out the debris with phlegm. During asthma, the muscles spasm (constricting) and the airway opening is getting much smaller. The smooth muscular layer has thickened and is clamping down on the opening. The mucosa layer has been compressed inward and decreases the lumen further. The glands continue to secrete mucous into the lumen which makes matters worse. Coughing and wheezing follow.
Conclusion:
Since OWC is already doing research on cannabinoids and their synergistic effects with the human immune system. Mainly focused on the functions dealing with white blood cells, cytokines and interleukins. Their studies could easily adapted for asthma since they will already have a wealth of information on how THC/CBD interact with certain immune functions. Just one more huge, exciting possibility for the company!
Sources:
https://www.youtube.com/watch?v=ZKvatbn4a_I (Asthma pathophysiology | Respiratory system)
https://www.youtube.com/watch?v=MoM5JY_EeRo Mast Cell (How Allergy Works)
https://www.youtube.com/watch?v=DZw--EZLEus (Asthma Cannabis Treatment Works Wonders On Lungs and Breathing)
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