There are no "Big Boys" shorting this stock, only obsessed bashers who apparently have a grudge. They're supported, deliberately or by default, by disillusioned shareholders or former shareholders who think there's some set formula that's supposed to be followed in growing a small biotechnology company. FYI, I didn't buy that series of CDs on making $10,000/week trading penny stocks with no problem. That's the series that followed flipping houses with no money down.