Which interleukins is OWC focusing on? IL1, IL2,
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Posted On: 04/20/2017 4:01:15 PM
Which interleukins is OWC focusing on?
IL1, IL2, IL3, IL8, IL10, IL13, IL15, IL17, IL20, IL23
IFN-gamma
TNF-alpha
"We have proven that it inhibits proliferation of keratinocytes. We are working on how does it manage in certain interleukins which cause inflammation. We are looking at the various interleukins to see what does medical cannabis, especially THC & CBD, do to those various interleukins. We have got already primary results. This study will be finished by the end of April and we can have the results published."
*CFN Interview with Dr. Yehuda Baruch, Chief Science Officer OWCP, starts at 2:57.
IL1 participates in the regulation of immune responses, inflammatory reactions and hematopoiesis (formation of blood cells).
IL2 regulates the growth and differentiation of T cells and certain B cells through the release of secreted protein factors. (T-cells cause inflammation, activate macrophages and get other T-cells fired up, regulate much of the immune response) (Types of T-cells include Helper, Cytotoxic, Memory, Suppressor, Natural Killer).
IL3 regulates hematopoiesis by controlling production, differentiation and function of granulocytes and macrophages.
IL8 induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection.
IL10 is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells.
IL13 is a pleiotropic cytokine that may be important in the regulation of the inflammatory and immune responses.
IL15 is a cytokine that possesses a variety of biological functions, including stimulation and maintenance of cellular immune responses
IL17 is a potent proinflammatory cytokine produced by activated memory T cells.
IL20 regulates proliferation and differentiation of keratinocytes.
IL23 maintenance of IL-17 producing cells, increases angiogenesis but reduces CD8 T-cell infiltration
IFN-gamma (interfering gamma activates macrophages and they turn into granulomas).
TNF-alpha is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages.
Conclusion:
There is more to the science than some would imagine. It is extremely complex and scientists are still making huge discoveries in this field. OWC is quickly getting their cream formulated and out to market to generate revenue ASAP. That is how confident they are in the research and product potential. As more studies are done and funded by the sales of creme via licensing, OWC will garner huge respect from the industry as they increase and secure their IP portfolio.
Sources:
https://en.wikipedia.org/wiki/Interleukin#Lis...terleukins
www.owcpharma.com/newsroom-photos/ [CFN Interview with Dr. Yehuda Baruch]
https://www.youtube.com/watch?v=aYNgLQNpA6E [Psoriasis and beyond: targeting the IL-17 pathway]
IL1, IL2, IL3, IL8, IL10, IL13, IL15, IL17, IL20, IL23
IFN-gamma
TNF-alpha
"We have proven that it inhibits proliferation of keratinocytes. We are working on how does it manage in certain interleukins which cause inflammation. We are looking at the various interleukins to see what does medical cannabis, especially THC & CBD, do to those various interleukins. We have got already primary results. This study will be finished by the end of April and we can have the results published."
*CFN Interview with Dr. Yehuda Baruch, Chief Science Officer OWCP, starts at 2:57.
IL1 participates in the regulation of immune responses, inflammatory reactions and hematopoiesis (formation of blood cells).
IL2 regulates the growth and differentiation of T cells and certain B cells through the release of secreted protein factors. (T-cells cause inflammation, activate macrophages and get other T-cells fired up, regulate much of the immune response) (Types of T-cells include Helper, Cytotoxic, Memory, Suppressor, Natural Killer).
IL3 regulates hematopoiesis by controlling production, differentiation and function of granulocytes and macrophages.
IL8 induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection.
IL10 is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells.
IL13 is a pleiotropic cytokine that may be important in the regulation of the inflammatory and immune responses.
IL15 is a cytokine that possesses a variety of biological functions, including stimulation and maintenance of cellular immune responses
IL17 is a potent proinflammatory cytokine produced by activated memory T cells.
IL20 regulates proliferation and differentiation of keratinocytes.
IL23 maintenance of IL-17 producing cells, increases angiogenesis but reduces CD8 T-cell infiltration
IFN-gamma (interfering gamma activates macrophages and they turn into granulomas).
TNF-alpha is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages.
Conclusion:
There is more to the science than some would imagine. It is extremely complex and scientists are still making huge discoveries in this field. OWC is quickly getting their cream formulated and out to market to generate revenue ASAP. That is how confident they are in the research and product potential. As more studies are done and funded by the sales of creme via licensing, OWC will garner huge respect from the industry as they increase and secure their IP portfolio.
Sources:
https://en.wikipedia.org/wiki/Interleukin#Lis...terleukins
www.owcpharma.com/newsroom-photos/ [CFN Interview with Dr. Yehuda Baruch]
https://www.youtube.com/watch?v=aYNgLQNpA6E [Psoriasis and beyond: targeting the IL-17 pathway]
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