Kevetrin poster presenting at AARC is friggin awes

Kevetrin poster presenting at AARC is friggin awesome.

https://static1.squarespace.com/static/571535...7MAR30.pdf

Excerpt
•Kevetrin induced apoptosis in wild type p53, mutant p53 and
partially deleted p53 ovarian cancer cell lines as assayed by
cleavage of PARP.
•p53 and p21 increased protein levels were seen in A2780 cells (p53
wild type) after 24 to 48 hr exposure to Kevetrin. Depletion of p53
by SiRNA reduced the p21 expression as assayed by FACS.
•Kevetrin downregulated oncogenic mutant p53 in OVCAR-3 and
OV-90 (p53 mutant)
• Increase in p21 mRNA in response to Kevetrin was observed in all
OC cell lines.
• No significant changes were observed in p53 mRNA.
• In xenograft models, Kevetrin inhibited A2780 tumor growth, and
increased SKOV-3 animal survival.
•Transcriptomic analyses demonstrated that Kevetrin modulates p53
signaling pathways and induces apoptosis and cell cycle arrest in
ovarian cancer cell lines as well as xenograft tumors as shown by
RNAseq data. KEGG pathway analysis was used for these studies.
• Altered expression of miRNA-27a, miRNA-1274b, miRNA-25
(known to be dysregulated in ovarian cancer) in a time-dependent
manner in OVCAR-3 cells provides possible biomarkers for
Kevetrin response.
• In tumors where p53 is partially deleted (SKOV-3), Kevetrin
modulates p53 pathways and induces apoptosis. Further detailed
mechanism studies are ongoing.

Saving this PDF. The OC trial is underway. I want more trials underway ASAP.

I forget if anyone was attending the presentation, I hope so, and I hope they share their thoughts/communications.